Cytogenetic study of non-Hodgkin lymphoma from South India: histologic and geographic correlations

Cytogenetic analysis of fine needle aspiration cultures was performed on 189 patients with non-Hodgkin lymphoma from South India. Successful karyotyping was possible in 97 patients (51.3%). Burkitt lymphoma constituted 56% of the cases studied followed by diffuse type 20%, follicular 8.8%, lymphobla...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2003-02, Vol.141 (1), p.14-19
Main Authors: Kumari, Prasanna, Mukherjee, Geetashree, Rao, Clementina Rama, Devi, Muniyappa Gayathri, Biswas, Siddhartha, Appaji, Lingegowda, Arunakumari, Bandagadde S., Padma, Maneya, Bapsy, Poonamallee Parthasarthy, Sundareshan, Tambarahalli S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Burkitt Lymphoma - epidemiology
Burkitt Lymphoma - genetics
Child
Child, Preschool
Chromosome Aberrations
Female
Hematologic and hematopoietic diseases
Humans
India - epidemiology
Karyotyping
Leukemia, Lymphoid - epidemiology
Leukemia, Lymphoid - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Follicular - epidemiology
Lymphoma, Follicular - genetics
Lymphoma, Non-Hodgkin - epidemiology
Lymphoma, Non-Hodgkin - genetics
Male
Medical sciences
Middle Aged
Tropical medicine
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Summary:Cytogenetic analysis of fine needle aspiration cultures was performed on 189 patients with non-Hodgkin lymphoma from South India. Successful karyotyping was possible in 97 patients (51.3%). Burkitt lymphoma constituted 56% of the cases studied followed by diffuse type 20%, follicular 8.8%, lymphoblastic 6.6%, and unclassified 6.6%. Characteristic chromosomal translocations were t(8;14)(q24;q32) [32.2%], t(8;22)(q24;q11) [10%], t(2;8)(p12;q24) [2.2%], t(14;18)(q34;q21) [3.3%], and t(11;14)(q23;q32) [2.2%]. Notable geographical variation of some structural abnormalities was the finding in the present study such as, lower frequency of t(14;18) in follicular lymphomas and higher frequency of t(8;14) in Burkitt lymphomas when compared with the Western studies.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(02)00648-9