Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production

The G protein beta gamma-dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein gamma(7)-subu...

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Bibliographic Details
Published in:The Journal of biological chemistry 2003-02, Vol.278 (8), p.6575-6579
Main Authors: Schwindinger, William F, Betz, Kelly S, Giger, Kathryn E, Sabol, Angela, Bronson, Sarah K, Robishaw, Janet D
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Corpus Striatum - metabolism
Cyclic AMP - metabolism
Dimerization
DNA Primers
Female
GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins - deficiency
Heterotrimeric GTP-Binding Proteins - genetics
Heterotrimeric GTP-Binding Proteins - metabolism
Male
Mice
Mice, Knockout
Reverse Transcriptase Polymerase Chain Reaction
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Summary:The G protein beta gamma-dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein gamma(7)-subunit in mice. Notably, deletion of Gng7 caused behavioral changes that were associated with reductions in the alpha(olf)-subunit content and adenylyl cyclase activity of the striatum. These data demonstrate that an individual gamma-subunit contributes to the specificity of a given signaling pathway and controls the formation or stability of a particular G protein heterotrimer.
ISSN:0021-9258