Transmission Fitness of Drug-Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral-Treated Population

Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antir...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-02, Vol.187 (4), p.683-686
Main Authors: Leigh Brown, Andrew J, Frost, Simon D. W, Mathews, W. Christopher, Dawson, Keith, Hellmann, Nicholas S, Daar, Eric S, Richman, Douglas D, Little, Susan J
Format: Article
Language:English
Subjects:
AIDS
Anti-HIV Agents - therapeutic use
Antiretrovirals
Arts
Biological and medical sciences
Data transmission
Disease transmission
Drug Resistance, Viral - genetics
Female
HIV
HIV 1
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - transmission
HIV-1 - drug effects
HIV-1 - genetics
HIV/AIDS
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
North America - epidemiology
Retrospective Studies
Transmitters
Treatment Failure
Urban Population
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Viruses
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Summary:Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only ∼20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains
ISSN:0022-1899
1537-6613
DOI:10.1086/367989