Proliferating cell nuclear antigen and Ki67 immunoreactivity in ameloblastomas

Objective. This study used proliferating cell nuclear antigen (PCNA) and Ki67 to evaluate and compare the in situ proliferative activity of (1) solid and multicystic and (2) unicystic ameloblastomas in an attempt to provide a scientific basis for any differences in biologic behavior that exists betw...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2003-02, Vol.95 (2), p.213-221
Main Authors: Meer, Shabnum, Galpin, Jacqueline S., Altini, Mario, Coleman, Hedley, Ali, Hasiena
Format: Article
Language:English
Subjects:
Ameloblastoma - chemistry
Ameloblastoma - pathology
Analysis of Variance
Biological and medical sciences
Cell Division
Dentistry
Ent. Stomatology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Jaw Neoplasms - chemistry
Jaw Neoplasms - pathology
Ki-67 Antigen - analysis
Medical sciences
Observer Variation
Otorhinolaryngology. Stomatology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proliferating Cell Nuclear Antigen - analysis
Tumors
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Summary:Objective. This study used proliferating cell nuclear antigen (PCNA) and Ki67 to evaluate and compare the in situ proliferative activity of (1) solid and multicystic and (2) unicystic ameloblastomas in an attempt to provide a scientific basis for any differences in biologic behavior that exists between these 2 groups of lesions. Study design. Twenty archival tissue sections, 10 of primary unicystic and 10 of solid and multicystic ameloblastomas, were immunohistochemically stained with PCNA and Ki67 antisera. Immunoreactivity was evaluated by the counting of cells, and the data obtained were statistically analyzed. Results. The results showed that cellular proliferative activity varied within the ameloblastoma types. The unicystic ameloblastomas showed statistically significantly higher PCNA and Ki67 labeling indices than the solid and multicystic variant. Conclusion. There appears, therefore, to be no correlation between proliferative activity as shown by these proteins and reported biologic behavior. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:213-21)
ISSN:1079-2104
1528-395X
DOI:10.1067/moe.2003.62