Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor

Activation of the angiotensin II type 1 (AT(1)) receptor is closely involved in the pathogenesis of cardiovascular diseases; therefore, aberrant regulation of the production of this receptor might play a role in these disorders. Currently, there is strong evidence to suggest that the predominant mec...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2003-03, Vol.14 (2), p.66-71
Main Authors: ELTON, Terry S, MARTIN, Mickey M
Format: Article
Language:English
Subjects:
Alternative Splicing
Amino Acid Sequence - genetics
Animals
Base Sequence - genetics
Biological and medical sciences
Cell receptors
Cell structures and functions
Exons
Fundamental and applied biological sciences. Psychology
Genetic Variation
Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors
Humans
Molecular and cellular biology
Molecular Sequence Data
Receptor, Angiotensin, Type 1
Receptors, Angiotensin - genetics
Receptors, Angiotensin - metabolism
RNA, Messenger - metabolism
Tissue Distribution
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Summary:Activation of the angiotensin II type 1 (AT(1)) receptor is closely involved in the pathogenesis of cardiovascular diseases; therefore, aberrant regulation of the production of this receptor might play a role in these disorders. Currently, there is strong evidence to suggest that the predominant mechanism regulating the number of AT(1) receptors is the modulation of mRNA stability. Here, we discuss the importance of alternative splicing as an additional post-transcriptional mechanism regulating human AT(1) receptor number and function.
ISSN:1043-2760
1879-3061
DOI:10.1016/S1043-2760(02)00038-3