C-13β-ACYLOXYMILBEMYCINS, A NEW FAMILY OF MACROLIDES: DISCOVERY, STRUCTURAL DETERMINATION AND BIOLOGICAL PROPERTIES

A family of novel milbemycins possessing C-13β-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.

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Bibliographic Details
Published in:Journal of antibiotics 1992/05/25, Vol.45(5), pp.659-670
Main Authors: MAXELL, MARK A., BISHOP, BERNARD F., BRYCE, PATRICIA, ORATION, KENNETH A. F., KARA, HAMIDA, MONDAY, ROBERT A., PACEY, MICHAEL S., PERRY, DAVID A., KOJIMA, YASUHIRO, MAEDA, HIROSHI, NISHIYAMA, SATOSHI, TONE, JUNSUKE, HUANG, LIANG H.
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - chemistry
Anthelmintics - isolation & purification
Anthelmintics - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Caenorhabditis - drug effects
Chemotherapic agents
Fundamental and applied biological sciences. Psychology
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Macrolides
Microbiology
Spiro Compounds - chemistry
Spiro Compounds - isolation & purification
Spiro Compounds - pharmacology
Streptomyces - chemistry
Streptomyces hygroscopicus
Structure-Activity Relationship
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Description
Summary:A family of novel milbemycins possessing C-13β-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.659