Postnatal Human Herpesvirus 8 and Human Immunodeficiency Virus Type 1 Infection in Mothers and Infants from Zambia

The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month pos...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-02, Vol.187 (4), p.559-568
Main Authors: Brayfield, Brad P, Phiri, Saul, Kankasa, Chipepo, Muyanga, Jubra, Mantina, Hamakwa, Kwenda, Geoffrey, West, John T, Bhat, Ganapati, Marx, Dave B, Klaskala, Winslow, Mitchell, Charles D, Wood, Charles
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Viral - blood
Biological and medical sciences
Children
Cohort Studies
Disease transmission
Disease Transmission, Infectious
Female
Herpesviridae
Herpesviridae Infections - blood
Herpesviridae Infections - epidemiology
Herpesviridae Infections - transmission
Herpesvirus 8, Human - immunology
Herpesvirus 8, Human - isolation & purification
HIV 1
HIV Antibodies - blood
HIV Infections - blood
HIV Infections - epidemiology
HIV/AIDS
Human herpesvirus 8
Human viral diseases
Humans
Incidence
Infant
Infant, Newborn
Infants
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Leukocytes, Mononuclear - virology
Male
Medical sciences
Mothers
Pregnancy
Pregnancy Complications, Infectious - blood
Pregnancy Complications, Infectious - epidemiology
Risk Factors
Seroepidemiologic Studies
Tropical medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Zambia - epidemiology
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Summary:The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8–positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8–positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes
ISSN:0022-1899
1537-6613
DOI:10.1086/367985