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Relationship of neural cell adhesion molecules (N-CAMs) with adenylate cyclase

Bovine brain cDNA cloned earlier and attributed to calmodulin-independent adenylate cyclase encodes the neural cell adhesion molecule (N-CAM). The expression of N-CAM mRNA in Xenopus laevis oocytes increases their basal adenylate cyclase activity. Polyclonal antibodies against synthetic peptide A, V...

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Published in:FEBS letters 1992-06, Vol.304 (1), p.9-11
Main Authors: Lipkin, V.M., Surina, E.A., Petukhova, G.V., Petrov, V.M., Mirzoeva, S.F., Rakitina, T.V.
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description Bovine brain cDNA cloned earlier and attributed to calmodulin-independent adenylate cyclase encodes the neural cell adhesion molecule (N-CAM). The expression of N-CAM mRNA in Xenopus laevis oocytes increases their basal adenylate cyclase activity. Polyclonal antibodies against synthetic peptide A, VAENQQGKSKAAHFV (664–678 amino acid residues of bovine N-CAM), containing sequence AXXXXGKS which is homologous to the nucleotide-binding consensus sequence GXXXXGKS, inhibit the adenylate cyclase activity. A close relationship appears to exist between adenylate cyclase and N-CAM.
doi_str_mv 10.1016/0014-5793(92)80577-4
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subjects Adenylate cyclase
Adenylyl Cyclases - genetics
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
bovine serum albumin
brain
BSA
Cattle
Cell Adhesion Molecules, Neuronal - genetics
Cloning, Molecular
ELISA
enzyme-linked immunosorbent assay
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Humans
interaction
Lyases
man
Molecular Sequence Data
N-CAM
NCAM protein
Neural cell adhesion molecule
Sequence Homology, Nucleic Acid
Xenopus laevis
γ-subunit of cGMP phosphodiesterase
γPDE
title Relationship of neural cell adhesion molecules (N-CAMs) with adenylate cyclase
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