Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophins, has been reported to ameliorate hyperglycemia in obese diabetic animal models. To elucidate the mechanism of BDNF on glucose metabolism, we determined the glucose turnover under basal and euglycemic hyperinsulinemic (insulin in...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2003-02, Vol.52 (2), p.203-208
Main Authors: Kuroda, Akio, Yamasaki, Yoshimitsu, Matsuhisa, Munehide, Kubota, Minoru, Nakahara, Itsuro, Nakatani, Yoshihisa, Hoshi, Ayumu, Gorogawa, Shin-ichi, Umayahara, Yutaka, Itakura, Yasushi, Nakagawa, Tsutomu, Taiji, Mutsuo, Kajimoto, Yoshitaka, Hori, Masatsugu
Format: Article
Language:English
Subjects:
Animals
Associated diseases and complications
Biological and medical sciences
Blood Glucose - analysis
Brain-Derived Neurotrophic Factor - pharmacology
Carboxy-Lyases - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Glucokinase - genetics
Glucose-6-Phosphatase - genetics
Glycogen - metabolism
Insulin - blood
Insulin Resistance
Liver - drug effects
Liver - physiopathology
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - physiopathology
Rats
Rats, Zucker
RNA, Messenger - metabolism
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Summary:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophins, has been reported to ameliorate hyperglycemia in obese diabetic animal models. To elucidate the mechanism of BDNF on glucose metabolism, we determined the glucose turnover under basal and euglycemic hyperinsulinemic (insulin infusion rate, 54 pmol · kg−1 · min−1) clamp conditions in obese insulin-resistant rats, male Zucker fatty rats, which had been acutely administered a subcutaneous injection of BDNF (20 mg/kg) (n = 9, BDNF) or vehicle (n = 8, vehicle). Under the basal condition, acute administration of BDNF did not affect the blood glucose level, plasma insulin level, rate of glucose disappearance (Rd), and endogenous glucose production (EGP). Under the clamp condition, the glucose infusion rate (GIR) was significantly higher in BDNF than in vehicle (mean ± SD, 61.4 ± 19.1 v 41.4 ± 4.9 μmol · kg−1 · min−1, P
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2003.50026