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Long‐Term Results of Guided Tissue Regeneration Therapy in the Treatment of Class II Furcation Defects: A Randomized Clinical Trial
Background: The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24‐month period. Methods: Nine patients with 2 comparable Class II furcation defects were included. The de...
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| Published in: | Journal of periodontology (1970) 2003-01, Vol.74 (1), p.3-9 |
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| container_title | Journal of periodontology (1970) |
| container_volume | 74 |
| creator | Cury, P.R. Sallum, E.A Nociti, F.H. Sallum, A.W. Jeffcoat, M.K. |
| description | Background: The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24‐month period.
Methods: Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient were randomly assigned to either test (GTR) or control (open flap debridement) group. Clinical measurements and standardized radiographs were taken at baseline, and at 6, 12, 18, and 24 months. The radiographs were analyzed by subtraction radiography.
Results: There were significant probing depth reductions for both test and control groups (P |
| doi_str_mv | 10.1902/jop.2003.74.1.3 |
| format | article |
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Methods: Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient were randomly assigned to either test (GTR) or control (open flap debridement) group. Clinical measurements and standardized radiographs were taken at baseline, and at 6, 12, 18, and 24 months. The radiographs were analyzed by subtraction radiography.
Results: There were significant probing depth reductions for both test and control groups (P <0.007, P <0.0005, respectively); however the differences between groups were not significant at any examination. The intra‐group and inter‐group differences in the vertical clinical attachment level gain were not significant (P >0.05). Over 24 months, a significant horizontal clinical attachment level gain was observed in the test group compared to control (P <0.03). In the test group, 2 sites showed complete closure, one was converted to Class I, and one tooth was lost due to root resorption. In the control group, 2 defects progressed to Class III over 24 months. At 6 months, the test group showed 0.14 mm of bone loss while the control group showed 0.86 mm of bone gain (P = 0.035). The inter‐group differences were not significant at 12, 18, and 24 months. A significant bone height gain was observed in the test group at 24 months when compared to the values obtained after 6 months (P = 0.015).
Conclusion: GTR may provide a greater horizontal clinical attachment level gain with the possibility of complete closure of some defects and stability over time. J Periodontol 2003;74:3‐9.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2003.74.1.3</identifier><identifier>PMID: 12593590</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Absorbable Implants ; Alveolar Process - diagnostic imaging ; Clinical trials ; Debridement ; Dentistry ; Disease Progression ; Female ; Follow-Up Studies ; Furcation Defects - classification ; Furcation Defects - diagnostic imaging ; Furcation Defects - surgery ; furcation/therapy ; guided tissue regeneration ; Guided Tissue Regeneration, Periodontal ; Humans ; Male ; Mandible - diagnostic imaging ; Mandible - surgery ; Membranes, Artificial ; Middle Aged ; Molar ; Periodontal Attachment Loss - classification ; Periodontal Attachment Loss - surgery ; Periodontal Pocket - classification ; Periodontal Pocket - surgery ; periodontal regeneration ; Radiography ; randomized ; Root Resorption - etiology ; Statistics as Topic ; Subtraction Technique ; Surgical Flaps ; Tooth Loss - etiology ; Wound Healing</subject><ispartof>Journal of periodontology (1970), 2003-01, Vol.74 (1), p.3-9</ispartof><rights>2003 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3393-9c079fae62dedec20911534d46586745efc5714e66b806e5d23170d66ac88c4b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12593590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cury, P.R.</creatorcontrib><creatorcontrib>Sallum, E.A</creatorcontrib><creatorcontrib>Nociti, F.H.</creatorcontrib><creatorcontrib>Sallum, A.W.</creatorcontrib><creatorcontrib>Jeffcoat, M.K.</creatorcontrib><title>Long‐Term Results of Guided Tissue Regeneration Therapy in the Treatment of Class II Furcation Defects: A Randomized Clinical Trial</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24‐month period.
Methods: Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient were randomly assigned to either test (GTR) or control (open flap debridement) group. Clinical measurements and standardized radiographs were taken at baseline, and at 6, 12, 18, and 24 months. The radiographs were analyzed by subtraction radiography.
Results: There were significant probing depth reductions for both test and control groups (P <0.007, P <0.0005, respectively); however the differences between groups were not significant at any examination. The intra‐group and inter‐group differences in the vertical clinical attachment level gain were not significant (P >0.05). Over 24 months, a significant horizontal clinical attachment level gain was observed in the test group compared to control (P <0.03). In the test group, 2 sites showed complete closure, one was converted to Class I, and one tooth was lost due to root resorption. In the control group, 2 defects progressed to Class III over 24 months. At 6 months, the test group showed 0.14 mm of bone loss while the control group showed 0.86 mm of bone gain (P = 0.035). The inter‐group differences were not significant at 12, 18, and 24 months. A significant bone height gain was observed in the test group at 24 months when compared to the values obtained after 6 months (P = 0.015).
Conclusion: GTR may provide a greater horizontal clinical attachment level gain with the possibility of complete closure of some defects and stability over time. J Periodontol 2003;74:3‐9.</description><subject>Absorbable Implants</subject><subject>Alveolar Process - diagnostic imaging</subject><subject>Clinical trials</subject><subject>Debridement</subject><subject>Dentistry</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Furcation Defects - classification</subject><subject>Furcation Defects - diagnostic imaging</subject><subject>Furcation Defects - surgery</subject><subject>furcation/therapy</subject><subject>guided tissue regeneration</subject><subject>Guided Tissue Regeneration, Periodontal</subject><subject>Humans</subject><subject>Male</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - surgery</subject><subject>Membranes, Artificial</subject><subject>Middle Aged</subject><subject>Molar</subject><subject>Periodontal Attachment Loss - classification</subject><subject>Periodontal Attachment Loss - surgery</subject><subject>Periodontal Pocket - classification</subject><subject>Periodontal Pocket - surgery</subject><subject>periodontal regeneration</subject><subject>Radiography</subject><subject>randomized</subject><subject>Root Resorption - etiology</subject><subject>Statistics as Topic</subject><subject>Subtraction Technique</subject><subject>Surgical Flaps</subject><subject>Tooth Loss - etiology</subject><subject>Wound Healing</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkDtv2zAUhYmiQeOmnbsVnLpJ4Uuk2C1wHnVhIIWhzgRNXSUMKMklJRTu1KV7f2N_SWnYQMZM9x7c7xxcHIQ-UFJSTdjl07grGSG8VKKkJX-FFlQLXnCpyGu0IISxggvNztHblJ6ypIKTN-icskrzSpMF-rMeh4d_v_82EHu8gTSHKeGxw3ezb6HFjU9phnx4gAGinfw44OYxb7s99gOeHgE3EezUwzAdbMtgU8KrFb6dozvi19CBm9JnfIU3dmjH3v_KwcvgB-9syHZvwzt01tmQ4P1pXqDvtzfN8kuxvr9bLa_WheNc80I7onRnQbL8GzhGNKUVF62QVS2VqKBzlaICpNzWRELVMk4VaaW0rq6d2PIL9OmYu4vjjxnSZHqfHIRgBxjnZBQngqiaZfDyCLo4phShM7voexv3hhJzaN7k5s2heaOEoYZnx8dT9LztoX3mT1VnoDoCP32A_Ut55uu3mw3Jmv8HkZGRBQ</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Cury, P.R.</creator><creator>Sallum, E.A</creator><creator>Nociti, F.H.</creator><creator>Sallum, A.W.</creator><creator>Jeffcoat, M.K.</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Long‐Term Results of Guided Tissue Regeneration Therapy in the Treatment of Class II Furcation Defects: A Randomized Clinical Trial</title><author>Cury, P.R. ; Sallum, E.A ; Nociti, F.H. ; Sallum, A.W. ; Jeffcoat, M.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3393-9c079fae62dedec20911534d46586745efc5714e66b806e5d23170d66ac88c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Absorbable Implants</topic><topic>Alveolar Process - diagnostic imaging</topic><topic>Clinical trials</topic><topic>Debridement</topic><topic>Dentistry</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Furcation Defects - classification</topic><topic>Furcation Defects - diagnostic imaging</topic><topic>Furcation Defects - surgery</topic><topic>furcation/therapy</topic><topic>guided tissue regeneration</topic><topic>Guided Tissue Regeneration, Periodontal</topic><topic>Humans</topic><topic>Male</topic><topic>Mandible - diagnostic imaging</topic><topic>Mandible - surgery</topic><topic>Membranes, Artificial</topic><topic>Middle Aged</topic><topic>Molar</topic><topic>Periodontal Attachment Loss - classification</topic><topic>Periodontal Attachment Loss - surgery</topic><topic>Periodontal Pocket - classification</topic><topic>Periodontal Pocket - surgery</topic><topic>periodontal regeneration</topic><topic>Radiography</topic><topic>randomized</topic><topic>Root Resorption - etiology</topic><topic>Statistics as Topic</topic><topic>Subtraction Technique</topic><topic>Surgical Flaps</topic><topic>Tooth Loss - etiology</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cury, P.R.</creatorcontrib><creatorcontrib>Sallum, E.A</creatorcontrib><creatorcontrib>Nociti, F.H.</creatorcontrib><creatorcontrib>Sallum, A.W.</creatorcontrib><creatorcontrib>Jeffcoat, M.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cury, P.R.</au><au>Sallum, E.A</au><au>Nociti, F.H.</au><au>Sallum, A.W.</au><au>Jeffcoat, M.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐Term Results of Guided Tissue Regeneration Therapy in the Treatment of Class II Furcation Defects: A Randomized Clinical Trial</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>74</volume><issue>1</issue><spage>3</spage><epage>9</epage><pages>3-9</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: The purpose of this study was to evaluate the results after guided tissue regeneration (GTR) using a bioabsorbable membrane in Class II furcation defects in mandibular molars over a 24‐month period.
Methods: Nine patients with 2 comparable Class II furcation defects were included. The defects in each patient were randomly assigned to either test (GTR) or control (open flap debridement) group. Clinical measurements and standardized radiographs were taken at baseline, and at 6, 12, 18, and 24 months. The radiographs were analyzed by subtraction radiography.
Results: There were significant probing depth reductions for both test and control groups (P <0.007, P <0.0005, respectively); however the differences between groups were not significant at any examination. The intra‐group and inter‐group differences in the vertical clinical attachment level gain were not significant (P >0.05). Over 24 months, a significant horizontal clinical attachment level gain was observed in the test group compared to control (P <0.03). In the test group, 2 sites showed complete closure, one was converted to Class I, and one tooth was lost due to root resorption. In the control group, 2 defects progressed to Class III over 24 months. At 6 months, the test group showed 0.14 mm of bone loss while the control group showed 0.86 mm of bone gain (P = 0.035). The inter‐group differences were not significant at 12, 18, and 24 months. A significant bone height gain was observed in the test group at 24 months when compared to the values obtained after 6 months (P = 0.015).
Conclusion: GTR may provide a greater horizontal clinical attachment level gain with the possibility of complete closure of some defects and stability over time. J Periodontol 2003;74:3‐9.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>12593590</pmid><doi>10.1902/jop.2003.74.1.3</doi><tpages>7</tpages></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Absorbable Implants Alveolar Process - diagnostic imaging Clinical trials Debridement Dentistry Disease Progression Female Follow-Up Studies Furcation Defects - classification Furcation Defects - diagnostic imaging Furcation Defects - surgery furcation/therapy guided tissue regeneration Guided Tissue Regeneration, Periodontal Humans Male Mandible - diagnostic imaging Mandible - surgery Membranes, Artificial Middle Aged Molar Periodontal Attachment Loss - classification Periodontal Attachment Loss - surgery Periodontal Pocket - classification Periodontal Pocket - surgery periodontal regeneration Radiography randomized Root Resorption - etiology Statistics as Topic Subtraction Technique Surgical Flaps Tooth Loss - etiology Wound Healing |
| title | Long‐Term Results of Guided Tissue Regeneration Therapy in the Treatment of Class II Furcation Defects: A Randomized Clinical Trial |
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