Use of protein electrophoresis in the diagnosis of cerebrospinal fluid rhinorrhoea

The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of noninvasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus sa...

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Bibliographic Details
Published in:Journal of laryngology and otology 1992-06, Vol.106 (6), p.504-506
Main Authors: Porter, M. J., Brookes, G. B., Zeman, A. Z. J., Keir, G.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cerebrospinal fluid
Cerebrospinal Fluid Proteins - analysis
Cerebrospinal Fluid Rhinorrhea - diagnosis
Electrophoresis
Electrophoresis, Agar Gel
Female
Humans
Main Articles
Male
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
tau Proteins - analysis
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of noninvasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus saved unnecessary invasive investigations or surgery. A modification of the method of analysis, which improves diagnostic accuracy, is described.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100119991