Evidence in vitro of glial cell priming in the taiep rat

Cultured glial cells from the cerebellum of 15-day-old taiep rats produced NO, increased iNOS levels, up-regulated iNOS expression and promoted TNF release when stimulated with LPS and IFNγ. These responses were much greater than in control cells. In taiep glial cells, NO production and iNOS levels...

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Bibliographic Details
Published in:Brain research 2003-03, Vol.965 (1), p.274-278
Main Authors: León-Chávez, Bertha A, Antonio Gonzalez-Barrios, Juan, Ugarte, Araceli, Meraz, Marco A, Martinez-Fong, Daniel
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Demyelinating Diseases - genetics
Demyelinating Diseases - immunology
Demyelinating Diseases - metabolism
Demyelination
Glial activation
Hypomyelination
LPS
Neuroglia - drug effects
Neuroglia - immunology
Neuroglia - metabolism
Nitric Oxide - immunology
Nitric Oxide - metabolism
Pro-inflammatory and anti-inflammatory cytokines
Rats
Rats, Mutant Strains
Rats, Sprague-Dawley
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Summary:Cultured glial cells from the cerebellum of 15-day-old taiep rats produced NO, increased iNOS levels, up-regulated iNOS expression and promoted TNF release when stimulated with LPS and IFNγ. These responses were much greater than in control cells. In taiep glial cells, NO production and iNOS levels and expression induced by the co-stimulatory signal were resistant to the inhibitory effect of TGFβ1. The glial cell priming might have been generated by oligodendrocyte alteration in taiep rats.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(02)04143-4