Anchor chain length alters the apparent mechanism of chloride channel function in SCMTR derivatives

Two membrane-anchored heptapeptides have been prepared and their pore-formation behavior in phospholipid bilayer membranes has been found to differ profoundly as a result only of alkyl chain length.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2003-02 (3), p.308-309
Main Authors: Schlesinger, Paul H, Djedovic, Natasha K, Ferdani, Riccardo, Pajewska, Jolanta, Pajewski, Robert, Gokel, George W
Format: Article
Language:English
Subjects:
Amines - chemistry
Chloride Channels - chemical synthesis
Chloride Channels - chemistry
Chloride Channels - physiology
Electric Conductivity
Fluoresceins
Liposomes
Membrane Proteins - chemical synthesis
Membrane Proteins - chemistry
Membrane Proteins - physiology
Membranes, Artificial
Models, Molecular
Porosity
Structure-Activity Relationship
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Description
Summary:Two membrane-anchored heptapeptides have been prepared and their pore-formation behavior in phospholipid bilayer membranes has been found to differ profoundly as a result only of alkyl chain length.
ISSN:1359-7345
1364-548X
DOI:10.1039/b211629b