The NKG2D receptor and its ligands–recognition beyond the “missing self”?

NKG2D is a surface receptor that activates natural killer (NK) cells and delivers a co-stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular stress and are specifically expressed by some tumor cells. This sparked the idea of an alternative regulation of NK cells by...

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Bibliographic Details
Published in:Microbes and Infection 2003, Vol.5 (1), p.31-37
Main Author: Watzl, Carsten
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Binding Sites
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
Cell interactions
Co-stimulation
Cytotoxicity, Immunologic
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Killer Cells, Natural - immunology
Ligands
Lymphocyte activation
Mice
NK Cell Lectin-Like Receptor Subfamily K
NK cells
Receptors, Cell Surface - metabolism
Receptors, Immunologic - metabolism
Receptors, Natural Killer Cell
Signal Transduction
T lymphocyte
Tumor immunity
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Summary:NKG2D is a surface receptor that activates natural killer (NK) cells and delivers a co-stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular stress and are specifically expressed by some tumor cells. This sparked the idea of an alternative regulation of NK cells by expression of “induced self” ligands on target cells which can overcome the inhibition imparted by MHC class I-specific inhibitory receptors.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(02)00057-6