Unexpected distribution of hepatitis C virus genotypes in patients on hemodialysis and kidney transplant recipients

The distribution of hepatitis C virus (HCV) genotypes in patients on hemodialysis and in kidney transplant recipients was compared with that observed in a control group composed of HCV‐infected individuals from the general population. A total of 340 patients were included in the study: 46 with end‐s...

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Bibliographic Details
Published in:Journal of medical virology 2003-04, Vol.69 (4), p.489-494
Main Authors: Perez, Renata M., Ferraz, Maria Lucia G., Figueiredo, Mauro S., Contado, Denilson, Koide, Sandra, Ferreira, Adalgisa P., Cendoroglo Neto, Miguel, Medina Pestana, José O., Silva, Antonio Eduardo B.
Format: Article
Language:English
Subjects:
5' Untranslated Regions - genetics
Adult
Biological and medical sciences
Female
Genotype
hemodialysis
Hepacivirus - classification
Hepacivirus - genetics
hepatitis C
Hepatitis C, Chronic - epidemiology
Hepatitis C, Chronic - virology
Human viral diseases
Humans
Infectious diseases
Kidney Transplantation
Male
Medical sciences
Middle Aged
Renal Dialysis
Sequence Analysis, DNA
Viral diseases
Viral hepatitis
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Summary:The distribution of hepatitis C virus (HCV) genotypes in patients on hemodialysis and in kidney transplant recipients was compared with that observed in a control group composed of HCV‐infected individuals from the general population. A total of 340 patients were included in the study: 46 with end‐stage renal disease on regular hemodialysis treatment, 22 kidney transplant recipients and 272 controls matched for sex and age at a 4:1 ratio (controls to patient). HCV genotype was determined by sequencing of the 5′ untranslated region of the HCV genome. No difference was observed in the distribution of HCV genotypes in hemodialysis patients and renal transplant patients (P = 0.47). However, when each of these groups was compared with the control group, a significant difference was detected in the genotype distribution (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.10336