L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE

A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to b...

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Bibliographic Details
Published in:Journal of antibiotics 1992/05/25, Vol.45(5), pp.679-685
Main Authors: ONDEYKA, J., HENSENS, O. D., ZINK, D., BALL, R., LINGHAM, R. B., BILLS, G., DOMBROWSKI, A., GOETZ, M.
Format: Article
Language:English
Subjects:
AIDS/HIV
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Ascomycota - chemistry
Biological and medical sciences
Chemotherapic agents
Cytochalasins - chemistry
Cytochalasins - isolation & purification
Cytochalasins - pharmacology
Fundamental and applied biological sciences. Psychology
HIV Protease Inhibitors
human immunodeficiency virus 1
Isoindoles
Microbiology
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Summary:A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.679