Loading…

L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE

A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to b...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of antibiotics 1992/05/25, Vol.45(5), pp.679-685
Main Authors:	ONDEYKA, J., HENSENS, O. D., ZINK, D., BALL, R., LINGHAM, R. B., BILLS, G., DOMBROWSKI, A., GOETZ, M.
Format:	Article
Language:	English
Subjects:	AIDS/HIV Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - chemistry Biological and medical sciences Chemotherapic agents Cytochalasins - chemistry Cytochalasins - isolation & purification Cytochalasins - pharmacology Fundamental and applied biological sciences. Psychology HIV Protease Inhibitors human immunodeficiency virus 1 Isoindoles Microbiology
Citations:	Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3
cites
container_end_page	685
container_issue	5
container_start_page	679
container_title	Journal of antibiotics
container_volume	45
creator	ONDEYKA, J. HENSENS, O. D. ZINK, D. BALL, R. LINGHAM, R. B. BILLS, G. DOMBROWSKI, A. GOETZ, M.
description	A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.
doi_str_mv	10.7164/antibiotics.45.679
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73056430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16493662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</originalsourceid><addsrcrecordid>eNqFkM1q4zAUhUWZ0kl_XmBgQIthVnWqf0tLJySNqYlLkxZmJWRZmnFwko6VLPr2VXFIs-tGWpzv3nP5APiB0TDFgt2Zza6pmu2usWHI-FCk6gwMsJQ4wUyob2CAEMGJlAR9B5chrBCiKU3lBbjAgjCaogEYFYlQ4haylN3CDM7Ll0kBx3-W5XiWFdkin8NsAbM5zOezfJQvyydYTuEsf0kwfHwql5NsMbkG5960wd0c_ivwPJ0sx7OkKO_zcVYklnGsEsYssSre5QhFTrhaEVzbSlaVrzjjxCufEi49Zs556jGqsK2R9zzygtSGXoHf_d7Xbvt_78JOr5tgXduajdvug04p4oJR9CUY1SkqBIkg6UHbbUPonNevXbM23ZvGSH8Y1ieGNeM6Go5DPw_b99Xa1Z8jvdKY_zrkJljT-s5sbBOOGKNcKYkj9tBjq7Azf90xN10sa91pM1ZCfrTz_olHHCn7z3Tabeg7X4-aUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16493662</pqid></control><display><type>article</type><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</title><source>J-STAGE Free Content</source><creator>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</creator><creatorcontrib>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</creatorcontrib><description>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.679</identifier><identifier>PMID: 1624370</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>AIDS/HIV ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Ascomycota - chemistry ; Biological and medical sciences ; Chemotherapic agents ; Cytochalasins - chemistry ; Cytochalasins - isolation & purification ; Cytochalasins - pharmacology ; Fundamental and applied biological sciences. Psychology ; HIV Protease Inhibitors ; human immunodeficiency virus 1 ; Isoindoles ; Microbiology</subject><ispartof>The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.679-685</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4359981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1624370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ONDEYKA, J.</creatorcontrib><creatorcontrib>HENSENS, O. D.</creatorcontrib><creatorcontrib>ZINK, D.</creatorcontrib><creatorcontrib>BALL, R.</creatorcontrib><creatorcontrib>LINGHAM, R. B.</creatorcontrib><creatorcontrib>BILLS, G.</creatorcontrib><creatorcontrib>DOMBROWSKI, A.</creatorcontrib><creatorcontrib>GOETZ, M.</creatorcontrib><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</description><subject>AIDS/HIV</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Ascomycota - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemotherapic agents</subject><subject>Cytochalasins - chemistry</subject><subject>Cytochalasins - isolation & purification</subject><subject>Cytochalasins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Protease Inhibitors</subject><subject>human immunodeficiency virus 1</subject><subject>Isoindoles</subject><subject>Microbiology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqFkM1q4zAUhUWZ0kl_XmBgQIthVnWqf0tLJySNqYlLkxZmJWRZmnFwko6VLPr2VXFIs-tGWpzv3nP5APiB0TDFgt2Zza6pmu2usWHI-FCk6gwMsJQ4wUyob2CAEMGJlAR9B5chrBCiKU3lBbjAgjCaogEYFYlQ4haylN3CDM7Ll0kBx3-W5XiWFdkin8NsAbM5zOezfJQvyydYTuEsf0kwfHwql5NsMbkG5960wd0c_ivwPJ0sx7OkKO_zcVYklnGsEsYssSre5QhFTrhaEVzbSlaVrzjjxCufEi49Zs556jGqsK2R9zzygtSGXoHf_d7Xbvt_78JOr5tgXduajdvug04p4oJR9CUY1SkqBIkg6UHbbUPonNevXbM23ZvGSH8Y1ieGNeM6Go5DPw_b99Xa1Z8jvdKY_zrkJljT-s5sbBOOGKNcKYkj9tBjq7Azf90xN10sa91pM1ZCfrTz_olHHCn7z3Tabeg7X4-aUA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>ONDEYKA, J.</creator><creator>HENSENS, O. D.</creator><creator>ZINK, D.</creator><creator>BALL, R.</creator><creator>LINGHAM, R. B.</creator><creator>BILLS, G.</creator><creator>DOMBROWSKI, A.</creator><creator>GOETZ, M.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE</title><author>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS/HIV</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Ascomycota - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemotherapic agents</topic><topic>Cytochalasins - chemistry</topic><topic>Cytochalasins - isolation & purification</topic><topic>Cytochalasins - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Protease Inhibitors</topic><topic>human immunodeficiency virus 1</topic><topic>Isoindoles</topic><topic>Microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ONDEYKA, J.</creatorcontrib><creatorcontrib>HENSENS, O. D.</creatorcontrib><creatorcontrib>ZINK, D.</creatorcontrib><creatorcontrib>BALL, R.</creatorcontrib><creatorcontrib>LINGHAM, R. B.</creatorcontrib><creatorcontrib>BILLS, G.</creatorcontrib><creatorcontrib>DOMBROWSKI, A.</creatorcontrib><creatorcontrib>GOETZ, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONDEYKA, J.</au><au>HENSENS, O. D.</au><au>ZINK, D.</au><au>BALL, R.</au><au>LINGHAM, R. B.</au><au>BILLS, G.</au><au>DOMBROWSKI, A.</au><au>GOETZ, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>5</issue><spage>679</spage><epage>685</epage><pages>679-685</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>1624370</pmid><doi>10.7164/antibiotics.45.679</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0021-8820
ispartof	The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.679-685
issn	0021-8820 1881-1469
language	eng
recordid	cdi_proquest_miscellaneous_73056430
source	J-STAGE Free Content
subjects	AIDS/HIV Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - chemistry Biological and medical sciences Chemotherapic agents Cytochalasins - chemistry Cytochalasins - isolation & purification Cytochalasins - pharmacology Fundamental and applied biological sciences. Psychology HIV Protease Inhibitors human immunodeficiency virus 1 Isoindoles Microbiology
title	L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T19%3A28%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=L-696,%20474,%20A%20NOVEL%20CYTOCHALASIN%20AS%20AN%20INHIBITOR%20OF%20HIV-1%20PROTEASE:%20II.%20ISOLATION%20AND%20STRUCTURE&rft.jtitle=Journal%20of%20antibiotics&rft.au=ONDEYKA,%20J.&rft.date=1992&rft.volume=45&rft.issue=5&rft.spage=679&rft.epage=685&rft.pages=679-685&rft.issn=0021-8820&rft.eissn=1881-1469&rft.coden=JANTAJ&rft_id=info:doi/10.7164/antibiotics.45.679&rft_dat=%3Cproquest_cross%3E16493662%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16493662&rft_id=info:pmid/1624370&rfr_iscdi=true