SYNTHESIS AND BIOLOGICAL PROPERTIES OF FCE 25199, A NEW ORAL PENEM

Preliminary data on the efficacy of FCE 25199 in mouse systemic infections, in comparison with the two oral penems under clinical evaluation and cefixime, are presented in Table 4. In these experiments the four compounds were tested in parallel against the listed pathogens. The ED sub(50)s for FCE 2...

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Bibliographic Details
Published in:Journal of antibiotics 1992/05/25, Vol.45(5), pp.797-801
Main Authors: ALPEGIANI, MARCO, BEDESCHI, ANGELO, ZARINI, FRANCO, BRUNA, COSTANTINO DELLA, JABES, DANIELA, PERRONE, ETTORE, FRANCESCHI, GIOVANNI
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacokinetics
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological Availability
Carbapenems - administration & dosage
Carbapenems - chemical synthesis
Carbapenems - pharmacokinetics
Female
Male
Medical sciences
Mice
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:Preliminary data on the efficacy of FCE 25199 in mouse systemic infections, in comparison with the two oral penems under clinical evaluation and cefixime, are presented in Table 4. In these experiments the four compounds were tested in parallel against the listed pathogens. The ED sub(50)s for FCE 25199 and FCE 22891 were comparable, and always lower than those of SUN 5555. In conclusion, FCE 25199 merits further development to assess its absorption and pharmacokinetics after oral dosing in humans.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.797