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Ambulatory Phlebectomy Versus Compression Sclerotherapy: Results of a Randomized Controlled Trial
BACKGROUND Although no randomized controlled trial has assessed the effects of either compression sclerotherapy or ambulatory phlebectomy, both techniques are used to treat varicose veins worldwide. We performed a randomized controlled trial to compare recurrence rates of varicose veins and complica...
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| Published in: | Dermatologic surgery 2003-03, Vol.29 (3), p.221-226 |
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| container_title | Dermatologic surgery |
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| creator | De Roos, Kees‐Peter Nieman, Fred H.M. Neumann, H.A. Martino |
| description | BACKGROUND Although no randomized controlled trial has assessed the effects of either compression sclerotherapy or ambulatory phlebectomy, both techniques are used to treat varicose veins worldwide. We performed a randomized controlled trial to compare recurrence rates of varicose veins and complications after compression sclerotherapy and ambulatory phlebectomy.
METHODS From September 1996 to October 1998, we randomly allocated 49 legs to compression sclerotherapy and 49 legs to ambulatory phlebectomy. Our primary outcome parameters were as follows: recurrence rates at 1 and 2 years and complications related to therapy. Eighty‐two patients were included, of whom 16 were included with both of their legs. The number of treated legs was therefore 98, but two patients were lost to follow‐up.
RESULTS One year recurrence amounted to 1 out of 48 for phlebectomy and 12 out of 48 for compression sclerotherapy (P |
| doi_str_mv | 10.1046/j.1524-4725.2003.29053.x |
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METHODS From September 1996 to October 1998, we randomly allocated 49 legs to compression sclerotherapy and 49 legs to ambulatory phlebectomy. Our primary outcome parameters were as follows: recurrence rates at 1 and 2 years and complications related to therapy. Eighty‐two patients were included, of whom 16 were included with both of their legs. The number of treated legs was therefore 98, but two patients were lost to follow‐up.
RESULTS One year recurrence amounted to 1 out of 48 for phlebectomy and 12 out of 48 for compression sclerotherapy (P<0.001); at 2 years, six additional recurrences were found, but then solely for compression sclerotherapy (P<0.001). Significant differences in complications occurring more in phlebectomy than in compression sclerotherapy therapy were blisters, teleangiectatic matting, scar formation, and bruising from bandaging.
CONCLUSION Our results show that ambulatory phlebectomy is an effective therapy for varicose veins of the leg. Recurrence rates are significantly lower than for compression sclerotherapy therapy. If varicose veins persist 4 weeks after compression sclerotherapy, it can be argued that to reduce the risk of future recurrence ambulatory phlebectomy should be considered as the better treatment option.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1046/j.1524-4725.2003.29053.x</identifier><identifier>PMID: 12614412</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Ambulatory Surgical Procedures ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Humans ; Logistic Models ; Medical sciences ; Plethysmography ; Prospective Studies ; Recurrence ; Sclerotherapy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Treatment Outcome ; Varicose Veins - surgery ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Vascular Surgical Procedures</subject><ispartof>Dermatologic surgery, 2003-03, Vol.29 (3), p.221-226</ispartof><rights>2003 by the American Society for Dermatologic Surgery, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5074-357eb647828639938d7df67660fd725f85ee511e308925d29a34ae58d1cfa75b3</citedby><cites>FETCH-LOGICAL-c5074-357eb647828639938d7df67660fd725f85ee511e308925d29a34ae58d1cfa75b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1524-4725.2003.29053.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1524-4725.2003.29053.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14652274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12614412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Roos, Kees‐Peter</creatorcontrib><creatorcontrib>Nieman, Fred H.M.</creatorcontrib><creatorcontrib>Neumann, H.A. Martino</creatorcontrib><title>Ambulatory Phlebectomy Versus Compression Sclerotherapy: Results of a Randomized Controlled Trial</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUND Although no randomized controlled trial has assessed the effects of either compression sclerotherapy or ambulatory phlebectomy, both techniques are used to treat varicose veins worldwide. We performed a randomized controlled trial to compare recurrence rates of varicose veins and complications after compression sclerotherapy and ambulatory phlebectomy.
METHODS From September 1996 to October 1998, we randomly allocated 49 legs to compression sclerotherapy and 49 legs to ambulatory phlebectomy. Our primary outcome parameters were as follows: recurrence rates at 1 and 2 years and complications related to therapy. Eighty‐two patients were included, of whom 16 were included with both of their legs. The number of treated legs was therefore 98, but two patients were lost to follow‐up.
RESULTS One year recurrence amounted to 1 out of 48 for phlebectomy and 12 out of 48 for compression sclerotherapy (P<0.001); at 2 years, six additional recurrences were found, but then solely for compression sclerotherapy (P<0.001). Significant differences in complications occurring more in phlebectomy than in compression sclerotherapy therapy were blisters, teleangiectatic matting, scar formation, and bruising from bandaging.
CONCLUSION Our results show that ambulatory phlebectomy is an effective therapy for varicose veins of the leg. Recurrence rates are significantly lower than for compression sclerotherapy therapy. If varicose veins persist 4 weeks after compression sclerotherapy, it can be argued that to reduce the risk of future recurrence ambulatory phlebectomy should be considered as the better treatment option.</description><subject>Ambulatory Surgical Procedures</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Plethysmography</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Sclerotherapy</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Treatment Outcome</subject><subject>Varicose Veins - surgery</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Vascular Surgical Procedures</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkEtv1TAQRiMEog_4C8gb2CWMX3HCAqm6QKlUqVUfbC0nmejm4sQXO1Ebfj1Ob9RukRce2eebsU-SEAoZBZF_3mVUMpEKxWTGAHjGSpA8e3yVHD9fvI41qDwFSdlRchLCDoCyksPb5IiynApB2XFizvpqsmZ0fibXW4sV1qPrZ_ILfZgC2bh-7zGEzg3ktrbo3bhFb_bzF3KDYbJjIK4lhtyYoXF99xebGBlG76yN5Z3vjH2XvGmNDfh-3U-T-x_f7zY_08ur84vN2WVaS1Ai5VJhlQtVsCLnZcmLRjVtrvIc2ib-pi0koqQUORQlkw0rDRcGZdHQujVKVvw0-XTou_fuz4Rh1H0XarTWDOimoBUHWTClIlgcwNq7EDy2eu-73vhZU9CLXr3Ti0W9WNSLXv2kVz_G6Id1xlT12LwEV58R-LgCJtTGtt4MdRdeOJFLxpSInDhwD86OUfVvOz2g11s0dtxqABBMsSJdhscFkMJyFmNf11hncf7vd-tvt_dPJf8H4E2l9w</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>De Roos, Kees‐Peter</creator><creator>Nieman, Fred H.M.</creator><creator>Neumann, H.A. Martino</creator><general>Blackwell Science Inc</general><general>by the American Society for Dermatologic Surgery, Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Ambulatory Phlebectomy Versus Compression Sclerotherapy: Results of a Randomized Controlled Trial</title><author>De Roos, Kees‐Peter ; Nieman, Fred H.M. ; Neumann, H.A. Martino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5074-357eb647828639938d7df67660fd725f85ee511e308925d29a34ae58d1cfa75b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Ambulatory Surgical Procedures</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Plethysmography</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Sclerotherapy</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Treatment Outcome</topic><topic>Varicose Veins - surgery</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><topic>Vascular Surgical Procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Roos, Kees‐Peter</creatorcontrib><creatorcontrib>Nieman, Fred H.M.</creatorcontrib><creatorcontrib>Neumann, H.A. Martino</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Roos, Kees‐Peter</au><au>Nieman, Fred H.M.</au><au>Neumann, H.A. Martino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ambulatory Phlebectomy Versus Compression Sclerotherapy: Results of a Randomized Controlled Trial</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2003-03</date><risdate>2003</risdate><volume>29</volume><issue>3</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUND Although no randomized controlled trial has assessed the effects of either compression sclerotherapy or ambulatory phlebectomy, both techniques are used to treat varicose veins worldwide. We performed a randomized controlled trial to compare recurrence rates of varicose veins and complications after compression sclerotherapy and ambulatory phlebectomy.
METHODS From September 1996 to October 1998, we randomly allocated 49 legs to compression sclerotherapy and 49 legs to ambulatory phlebectomy. Our primary outcome parameters were as follows: recurrence rates at 1 and 2 years and complications related to therapy. Eighty‐two patients were included, of whom 16 were included with both of their legs. The number of treated legs was therefore 98, but two patients were lost to follow‐up.
RESULTS One year recurrence amounted to 1 out of 48 for phlebectomy and 12 out of 48 for compression sclerotherapy (P<0.001); at 2 years, six additional recurrences were found, but then solely for compression sclerotherapy (P<0.001). Significant differences in complications occurring more in phlebectomy than in compression sclerotherapy therapy were blisters, teleangiectatic matting, scar formation, and bruising from bandaging.
CONCLUSION Our results show that ambulatory phlebectomy is an effective therapy for varicose veins of the leg. Recurrence rates are significantly lower than for compression sclerotherapy therapy. If varicose veins persist 4 weeks after compression sclerotherapy, it can be argued that to reduce the risk of future recurrence ambulatory phlebectomy should be considered as the better treatment option.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>12614412</pmid><doi>10.1046/j.1524-4725.2003.29053.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Ambulatory Surgical Procedures Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Humans Logistic Models Medical sciences Plethysmography Prospective Studies Recurrence Sclerotherapy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome Varicose Veins - surgery Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Vascular Surgical Procedures |
| title | Ambulatory Phlebectomy Versus Compression Sclerotherapy: Results of a Randomized Controlled Trial |
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