Occurrence of preformed volatile nitrosamines in preparations of some nigerian medicinal plants: a preliminary report

Preparations of some tropical plants of medicinal importance collected from the savannah vegetational belt of Nigeria were analysed for preformed volatile N-nitrosamines. N-nitrosamines were analyzed by chemiluminescence detection on a thermal energy analyzer (TEA) following gas chromatographic (GC)...

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Bibliographic Details
Published in:Food and chemical toxicology 2003-04, Vol.41 (4), p.551-554
Main Author: ATAWODI, S. E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromatography, Gas
Differential Thermal Analysis
Dimethylnitrosamine - analysis
Drug Contamination
Drug toxicity and drugs side effects treatment
Medical sciences
Medicine, African Traditional
Miscellaneous (drug allergy, mutagens, teratogens...)
Nigeria
Nitrates - analysis
Nitrites - analysis
Nitrosamines - analysis
Pharmacology. Drug treatments
Plant Preparations - analysis
Plants, Medicinal - chemistry
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Summary:Preparations of some tropical plants of medicinal importance collected from the savannah vegetational belt of Nigeria were analysed for preformed volatile N-nitrosamines. N-nitrosamines were analyzed by chemiluminescence detection on a thermal energy analyzer (TEA) following gas chromatographic (GC) separation. Only N-nitrosodimethylamine (NDMA) in the range of 1.2-3.4 microg/kg was detected in four out of the 29 sample preparations. These preliminary data suggest that medicinal plant preparations may be due in part to microbial contamination, contributing to N-nitroso compound burden in many developing countries where ethnomedicine in still widely practised.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(02)00304-6