Acquired cystic disease in chronically rejected renal transplants

Acquired cystic disease has been documented to complicate most forms of chronic renal damage; it has only infrequently been described in transplanted kidneys. Five patients with noncystic ESRD and chronically rejected transplants in which acquired cystic disease arose are reported. The diagnosis of...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 1992-02, Vol.2 (8), p.1298-1301
Main Authors: Chung, W Y, Nast, C C, Ettenger, R B, Danoviton, G M, Ward, H J, Cohen, A H
Format: Article
Language:English
Subjects:
Adult
Child
Female
Graft Rejection
Humans
Kidney Diseases, Cystic - etiology
Kidney Diseases, Cystic - pathology
Kidney Transplantation - immunology
Male
Middle Aged
Retrospective Studies
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Summary:Acquired cystic disease has been documented to complicate most forms of chronic renal damage; it has only infrequently been described in transplanted kidneys. Five patients with noncystic ESRD and chronically rejected transplants in which acquired cystic disease arose are reported. The diagnosis of acquired cystic disease was established in examination of transplant nephrectomies from four patients and a core biopsy from the fifth. The allografts were in place from 44 to 80 months; three patients were treated with hemodialysis before the diagnosis of acquired cystic disease, whereas two received peritoneal dialysis. Three of the four patients evaluated had cysts in the native kidneys. Although papillary hyperplasia of lining epithelium was evident in four specimens, only one kidney was the site of neoplasms in the form of multiple small tubular adenomas. No malignant neoplasms were noted in this study or in the few similar previous ones; however, it is possible that chronically rejected transplanted kidneys may harbor neoplasms with the same malignant potential as those in acquired cystic disease in native kidneys.
ISSN:1046-6673
DOI:10.1681/ASN.V281298