Measurements of the major isoforms of vitamins A and E and carotenoids in the blood of people with spinal-cord injuries

We used reversed-phase HPLC with diode array detection to simultaneously measure the major isoforms of vitamins A, E, and the carotenoids in serum from 55 healthy people with spinal cord injuries. Typically, the method measured retinol (vitamin A), α-tocopherol (vitamin E) and β-carotene, α-carotene...

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Bibliographic Details
Published in:Journal of Chromatography A 2003-02, Vol.987 (1), p.359-366
Main Authors: Burri, Betty Jane, Dopler-Nelson, Mindy, Neidllinger, Terry Ray
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carotenes
Carotenoids
Cerebrospinal fluid. Meninges. Spinal cord
Humans
Isomerism
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Spinal Cord Injuries - blood
Tocopherols
Vitamin A - blood
Vitamin E - blood
Vitamins
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Summary:We used reversed-phase HPLC with diode array detection to simultaneously measure the major isoforms of vitamins A, E, and the carotenoids in serum from 55 healthy people with spinal cord injuries. Typically, the method measured retinol (vitamin A), α-tocopherol (vitamin E) and β-carotene, α-carotene, lutein, lycopene, and cryptoxanthin (carotenoids). γ-Tocopherol (vitamin E), 25-hydroxycalciferol (vitamin D), and the carotenoid zeaxanthin could also be measured when they were present in high concentrations. Healthy people with spinal cord injuries were more likely than similar people without injuries to have low concentrations of α-tocopherol, and to a lesser extent retinol and β-carotene.
ISSN:0021-9673
DOI:10.1016/S0021-9673(02)01908-8