Characterization of Prominin-2, a New Member of the Prominin Family of Pentaspan Membrane Glycoproteins

Prominin/CD133 is a 115/120-kDa integral membrane glycoprotein specifically associated with plasma membrane protrusions in epithelial and non-epithelial cells including neuroepithelial and hematopoietic stem cells. Here we report the identification as well as molecular and cell biological characteri...

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Bibliographic Details
Published in:The Journal of biological chemistry 2003-03, Vol.278 (10), p.8586-8596
Main Authors: Fargeas, Christine A, Florek, Mareike, Huttner, Wieland B, Corbeil, Denis
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cloning, Molecular
DNA, Complementary
Expressed Sequence Tags
Eye - metabolism
Humans
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Mice
Microscopy, Fluorescence
Molecular Sequence Data
Rats
RNA, Messenger - genetics
Sequence Homology, Amino Acid
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Summary:Prominin/CD133 is a 115/120-kDa integral membrane glycoprotein specifically associated with plasma membrane protrusions in epithelial and non-epithelial cells including neuroepithelial and hematopoietic stem cells. Here we report the identification as well as molecular and cell biological characterization of mouse, rat, and human prominin-2, a 112-kDa glycoprotein structurally related to prominin (referred to as prominin-1). Although the amino acid identity between prominin-2 and prominin-1 is low (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M210640200