Protective immunity against pasteurellosis in cattle, induced by Pasteurella haemolytica ghosts

Pasteurella haemolytica is a cattle pathogen of significant economic impact. An effective vaccine against bovine pneumonic pasteurellosis is therefore of high importance. Apart from economic concerns, pasteurellosis caused by P. haemolytica is a serious disease leading to death in cattle if it remai...

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Bibliographic Details
Published in:Vaccine 2003-03, Vol.21 (13), p.1415-1422
Main Authors: Marchart, J., Rehagen, M., Dropmann, G., Szostak, M.P., Alldinger, S., Lechleitner, S., Schlapp, T., Resch, S., Lubitz, W.
Format: Article
Language:English
Subjects:
Animals
Bacterial ghost
Bacterial Vaccines - immunology
Cattle
Cattle Diseases - prevention & control
Fermentation
Immunization
Mannheimia haemolytica
Mannheimia haemolytica - immunology
Pasteurella Infections - prevention & control
Pasteurella Infections - veterinary
Plasmids
Protection
Vaccine
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Summary:Pasteurella haemolytica is a cattle pathogen of significant economic impact. An effective vaccine against bovine pneumonic pasteurellosis is therefore of high importance. Apart from economic concerns, pasteurellosis caused by P. haemolytica is a serious disease leading to death in cattle if it remains untreated. In this study P. haemolytica—ghosts are presented as a promising vaccine candidate in cattle. To obtain sufficient vaccination material a fermentation protocol for P. haemolytica—ghost production was established. With the obtained experimental P. haemolytica—ghost vaccine, cattle immunization studies were performed based on a Pasteurella cattle challenge model developed specifically for vaccine validation. It was shown that protective immunization of cattle against homologous challenge was induced by adjuvanted P. haemolytica—ghosts. The level of protection was similar to a commercially available vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(02)00635-7