Orexin A (hypocretin-1) application at the medial preoptic area potentiates male sexual behavior in rats

The medial preoptic area plays an important role in the regulation of male sexual behavior in rats, and this area receives orexinergic inputs. The role of orexinergic inputs in the medial preoptic area in sexual behavior has not been studied, though they have been shown to play a role in some other...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2003-01, Vol.116 (4), p.921-923
Main Authors: Gulia, K.K, Mallick, H.N, Kumar, V.M
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
Carrier Proteins - pharmacology
Fundamental and applied biological sciences. Psychology
hypocretin-1
Intracellular Signaling Peptides and Proteins
Male
medial preoptic area
Neuropeptides - pharmacology
Neurotransmission and behavior
orexin A
Orexins
Preoptic Area - drug effects
Preoptic Area - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
sexual behavior
Sexual Behavior, Animal - drug effects
Sexual Behavior, Animal - physiology
wakefulness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The medial preoptic area plays an important role in the regulation of male sexual behavior in rats, and this area receives orexinergic inputs. The role of orexinergic inputs in the medial preoptic area in sexual behavior has not been studied, though they have been shown to play a role in some other physiological functions. In this study, the changes in male sexual behavior in rats were studied after local injection of orexin A (Hypocretin-1) at the medial preoptic area. The results of the study showed that orexin A application at the medial preoptic area increased sexual arousal as well as the copulatory performance. Sexual arousal is one of the physiological stimuli, which influences wakefulness. It is possible that the earlier reports showing increased wakefulness (Espana et al., 2001; Thakkar et al., 2001), on application of orexin A at the medial preoptic area/basal forebrain, has a contribution from sexual arousal.
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(02)00877-1