Transcriptional repression by Myc

The Myc oncoprotein is a transcription factor that can both activate and repress genes. Transcriptional activation by Myc is well understood, but, by contrast, the mechanisms through which Myc represses transcription have remained elusive. Recent evidence suggests that complex formation by Myc with...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2003-03, Vol.13 (3), p.146-150
Main Authors: Wanzel, Michael, Herold, Steffi, Eilers, Martin
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Cell Cycle Proteins - genetics
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Eukaryotic Cells - metabolism
Genes, APC - physiology
Humans
Kruppel-Like Transcription Factors
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Repressor Proteins - genetics
Silencer Elements, Transcriptional - genetics
Transcription Factors
Tumor Suppressor Proteins - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Myc oncoprotein is a transcription factor that can both activate and repress genes. Transcriptional activation by Myc is well understood, but, by contrast, the mechanisms through which Myc represses transcription have remained elusive. Recent evidence suggests that complex formation by Myc with a zinc-finger transcription factor, Miz-1, plays an important role in mediating repression by Myc. The findings might explain how Myc interferes with cell-cycle arrest in response to TGF-β, APC and DNA damage.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(03)00003-5