Slit and robo: expression patterns in lung development

First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 an...

Full description

Saved in:
Bibliographic Details
Published in:Gene Expression Patterns 2003-03, Vol.3 (1), p.13-19
Main Authors: Anselmo, Mark A, Dalvin, Sussie, Prodhan, Parthak, Komatsuzaki, Katsumi, Aidlen, Jeremy T, Schnitzer, Jay J, Wu, Jane Y, Bernard Kinane, T
Format: Article
Language:English
Subjects:
Animals
Branching morphogenesis
Drosophila Proteins
Gene Expression Profiling
Lung - embryology
Lung - metabolism
Lung development
Mice
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Receptors, Immunologic - biosynthesis
Receptors, Immunologic - genetics
Robo
Roundabout Proteins
Slit
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-1 and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-1 and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development.
ISSN:1567-133X
1872-7298
DOI:10.1016/S1567-133X(02)00095-9