Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells

Several quinolines were synthesized and evaluated against HTLV-1 infected cells. Some of them were able to inhibit HTLV-1 cell-growth at 10 μM. Some structure–activity relationships were observed. Twenty-nine 2-substituted quinolines were synthesized and evaluated against HTLV-1 transformed cell lin...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-03, Vol.13 (5), p.891-894
Main Authors: Fournet, Alain, Mahieux, Renaud, Fakhfakh, Mohammed A, Franck, Xavier, Hocquemiller, Reynald, Figadère, Bruno
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Cell Division - drug effects
Cell Line
Cell Transformation, Viral
General pharmacology
HTLV-I Infections - drug therapy
Human T-lymphotropic virus 1 - drug effects
Human T-lymphotropic virus 1 - growth & development
Humans
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Quinolines - chemistry
Quinolines - pharmacology
Structure-Activity Relationship
T-Lymphocytes - cytology
T-Lymphocytes - microbiology
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Summary:Several quinolines were synthesized and evaluated against HTLV-1 infected cells. Some of them were able to inhibit HTLV-1 cell-growth at 10 μM. Some structure–activity relationships were observed. Twenty-nine 2-substituted quinolines were synthesized and evaluated against HTLV-1 transformed cell lines. Several of these showed around 85% inhibition at 10 μM.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)01085-5