Skin involvement in invasive breast carcinoma: safety of skin-sparing mastectomy

There is concern about the oncological safety of preserving most of the breast skin in skin-sparing mastectomy (SSM). Most supportive evidence for SSM evaluates the local recurrence rate on clinical follow-up. The skin and 10 mm of the subcutaneous tissue of 30 total mastectomy specimens were studie...

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Bibliographic Details
Published in:Annals of surgical oncology 2003-03, Vol.10 (2), p.102-107
Main Authors: Ho, Chiu M, Mak, Colin K L, Lau, Yvonne, Cheung, Wing Y, Chan, Miranda C M, Hung, Wai K
Format: Article
Language:English
Subjects:
Adult
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Chi-Square Distribution
Female
Humans
Incidence
Mammaplasty
Mastectomy - methods
Middle Aged
Neoplasm Recurrence, Local
Safety
Skin Neoplasms - epidemiology
Surgical Flaps
Treatment Outcome
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Summary:There is concern about the oncological safety of preserving most of the breast skin in skin-sparing mastectomy (SSM). Most supportive evidence for SSM evaluates the local recurrence rate on clinical follow-up. The skin and 10 mm of the subcutaneous tissue of 30 total mastectomy specimens were studied with a step-serial sectioning technique. The incidence and mode of involvement of the skin and subcutaneous tissue were recorded in detail. This was correlated with other clinical and pathologic parameters. The incidence of skin involvement outside the nipple-areola complex was 20% (6 of 30). This was significantly related to the clinical T stage, site of the tumor, skin tethering, pathologic tumor size, and perineural infiltration. When the effects of both skin and subcutaneous tissue involvement were considered, the incidence of skin-flap involvement outside the nipple-areola complex was 23% (7 of 30). The significant parameters related to skin-flap involvement were skin tethering (75% vs. 15%; P
ISSN:1068-9265
1534-4681
DOI:10.1245/ASO.2003.05.001