An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum...

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Bibliographic Details
Published in:Clinical and experimental medicine 2003-02, Vol.2 (4), p.171-174
Main Authors: MUTLU-TÜRKOGLU, Ü, ÖZTEZCAN, S, TELCI, A, ORHAN, Y, AYKAC-TOKER, G, SIVAS, A, UYSAL, M
Format: Article
Language:English
Subjects:
Adult
Arteriosclerosis - metabolism
Biological and medical sciences
Body Mass Index
Cholesterol - blood
Female
Humans
Lipid Peroxides - blood
Lipids
Lipoproteins, LDL - metabolism
Malondialdehyde - blood
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - metabolism
Oxidation
Oxidation-Reduction
Risk Factors
Statistics as Topic
Women
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Summary:Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoproteincholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoproteincholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.
ISSN:1591-8890
1591-9528
DOI:10.1007/s102380300002