Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis

The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity. Although these findings suggest an association with insulin resistance and atherosclerosis, this hypothesis has yet been tested only partially. To investigate this hypothes...

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Bibliographic Details
Published in:Stroke (1970) 2003-03, Vol.34 (3), p.605-609
Main Authors: Wascher, Thomas C, Paulweber, Bernhard, Malaimare, Liliane, Stadlmayr, Andreas, Iglseder, Bernhard, Schmoelzer, Isabella, Renner, Wilfried
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Austria - epidemiology
Blood Pressure - genetics
Body Constitution - genetics
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - genetics
Cohort Studies
Comorbidity
DNA Mutational Analysis
European Continental Ancestry Group - genetics
Female
Gene Frequency
Heterotrimeric GTP-Binding Proteins - genetics
Humans
Hypertension - epidemiology
Insulin Resistance - genetics
Male
Middle Aged
Polymorphism, Genetic
Prevalence
Protein Subunits - genetics
Ultrasonography
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Summary:The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity. Although these findings suggest an association with insulin resistance and atherosclerosis, this hypothesis has yet been tested only partially. To investigate this hypothesis, the C825T dimorphism was determined in a population of 932 middle-aged white subjects of middle European (Austrian) origin. Insulin sensitivity was measured with the short insulin tolerance test; intima-media thickness of the carotid artery and morphological plaque burden were measured by ultrasound. Insulin sensitivity was found to be significantly lower in carriers of the T allele (3.55+/-1.27 versus 3.92+/-1.30%/min, P=0.012) in the group of male subjects with abdominal body fat distribution (waist-to-hip ratio >0.9). No effect was observed in women or men with a waist-to-hip ratio
ISSN:0039-2499
1524-4628