Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade

1  Departments of Physiology and Biophysics and 2  Internal Medicine, University of Campinas 6040 Campinas; and 3  Department of Physiology and Biophysics, University of São Paulo, 05508-900 Sao Paulo, Brazil Short-term muscle denervation is a reproducible model of tissue-specific insulin resistance...

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Published in:American journal of physiology: endocrinology and metabolism 2003-04, Vol.284 (4), p.E679-E687
Main Authors: Bertelli, Daniela F, Ueno, Miriam, Amaral, Maria E. C, Toyama, Marcos Hikari, Carneiro, Everardo M, Marangoni, Sergio, Carvalho, Carla R. O, Saad, Mario J. A, Velloso, Licio A, Boschero, A. Carlos
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Disease Models, Animal
Hypoglycemic Agents - pharmacology
Insulin - pharmacology
Insulin Resistance
Male
Muscle Denervation
Muscle, Skeletal - innervation
Muscle, Skeletal - metabolism
Oligonucleotides, Antisense - pharmacology
Phosphatidylinositol 3-Kinases - metabolism
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Phosphatidylinositols - metabolism
Phosphoric Monoester Hydrolases - antagonists & inhibitors
Phosphoric Monoester Hydrolases - genetics
Phosphoric Monoester Hydrolases - metabolism
Phosphorylation
Rats
Rats, Wistar
Signal Transduction - drug effects
Tyrosine - metabolism
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Summary:1  Departments of Physiology and Biophysics and 2  Internal Medicine, University of Campinas 6040 Campinas; and 3  Department of Physiology and Biophysics, University of São Paulo, 05508-900 Sao Paulo, Brazil Short-term muscle denervation is a reproducible model of tissue-specific insulin resistance. To investigate the molecular basis of insulin resistance in denervated muscle, the downstream signaling molecules of the insulin-signaling pathway were examined in intact and denervated soleus muscle of rats. Short-term denervation induced a significant fall in glucose clearance rates (62% of control, P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00345.2002