Transforming Growth Factor-β in Leishmanial Infection: A Parasite Escape Mechanism

The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infecti...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5069), p.545-548
Main Authors: Barral-Netto, Manoel, Barral, Aldina, Brownell, Cari E., Yasir A. W. Skeiky, Ellingsworth, Larry R., Twardzik, Daniel R., Reed, Steven G.
Format: Article
Language:English
Subjects:
Actins - genetics
Animals
Base Sequence
Biological and medical sciences
Cytokines
Development and progression
Disease Susceptibility
Experimental protozoal diseases and models
Healing
Infections
Infectious diseases
Interferon-gamma - genetics
Interleukin-4 - genetics
Leishmania - pathogenicity
Leishmania - physiology
Leishmaniasis
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - pathology
Leishmaniasis, Cutaneous - physiopathology
Lesions
Macrophages
Macrophages - drug effects
Macrophages - parasitology
Medical sciences
Messenger RNA
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Oligodeoxyribonucleotides
Parasite hosts
Parasites
Parasitic diseases
Polymerase Chain Reaction - methods
Protozoal diseases
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - pharmacology
Transforming Growth Factor beta - physiology
Transforming growth factors
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Summary:The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-β (TGF-β) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-β, both in vitro and in vivo. TGF-β was important for determining in vivo susceptibility to experimental leishmanial infection.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1636092