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Transforming Growth Factor-β in Leishmanial Infection: A Parasite Escape Mechanism
The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infecti...
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| Published in: | Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5069), p.545-548 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c647t-928c4bb049f2b05a804bfdc4c855e9ce574e4c5d8fe4ee9d342d50a108b397ec3 |
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| cites | cdi_FETCH-LOGICAL-c647t-928c4bb049f2b05a804bfdc4c855e9ce574e4c5d8fe4ee9d342d50a108b397ec3 |
| container_end_page | 548 |
| container_issue | 5069 |
| container_start_page | 545 |
| container_title | Science (American Association for the Advancement of Science) |
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| creator | Barral-Netto, Manoel Barral, Aldina Brownell, Cari E. Yasir A. W. Skeiky Ellingsworth, Larry R. Twardzik, Daniel R. Reed, Steven G. |
| description | The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-β (TGF-β) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-β, both in vitro and in vivo. TGF-β was important for determining in vivo susceptibility to experimental leishmanial infection. |
| doi_str_mv | 10.1126/science.1636092 |
| format | article |
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W. Skeiky ; Ellingsworth, Larry R. ; Twardzik, Daniel R. ; Reed, Steven G.</creator><creatorcontrib>Barral-Netto, Manoel ; Barral, Aldina ; Brownell, Cari E. ; Yasir A. W. Skeiky ; Ellingsworth, Larry R. ; Twardzik, Daniel R. ; Reed, Steven G.</creatorcontrib><description>The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infection. Transforming growth factor-β (TGF-β) is a multipotential cytokine with diverse effects on cells of the immune system, including down-regulation of certain macrophage functions. Leishmanial infection induced the production of active TGF-β, both in vitro and in vivo. TGF-β was important for determining in vivo susceptibility to experimental leishmanial infection.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1636092</identifier><identifier>PMID: 1636092</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Actins - genetics ; Animals ; Base Sequence ; Biological and medical sciences ; Cytokines ; Development and progression ; Disease Susceptibility ; Experimental protozoal diseases and models ; Healing ; Infections ; Infectious diseases ; Interferon-gamma - genetics ; Interleukin-4 - genetics ; Leishmania - pathogenicity ; Leishmania - physiology ; Leishmaniasis ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - pathology ; Leishmaniasis, Cutaneous - physiopathology ; Lesions ; Macrophages ; Macrophages - drug effects ; Macrophages - parasitology ; Medical sciences ; Messenger RNA ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Parasite hosts ; Parasites ; Parasitic diseases ; Polymerase Chain Reaction - methods ; Protozoal diseases ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - pharmacology ; Transforming Growth Factor beta - physiology ; Transforming growth factors</subject><ispartof>Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5069), p.545-548</ispartof><rights>Copyright 1992 American Association for the Advancement of Science</rights><rights>1992 INIST-CNRS</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c647t-928c4bb049f2b05a804bfdc4c855e9ce574e4c5d8fe4ee9d342d50a108b397ec3</citedby><cites>FETCH-LOGICAL-c647t-928c4bb049f2b05a804bfdc4c855e9ce574e4c5d8fe4ee9d342d50a108b397ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2884,2885,27924,27925,33612,33878</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5433705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1636092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barral-Netto, Manoel</creatorcontrib><creatorcontrib>Barral, Aldina</creatorcontrib><creatorcontrib>Brownell, Cari E.</creatorcontrib><creatorcontrib>Yasir A. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5069), p.545-548 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73090890 |
| source | American Association for the Advancement of Science; Social Science Premium Collection; Education Collection |
| subjects | Actins - genetics Animals Base Sequence Biological and medical sciences Cytokines Development and progression Disease Susceptibility Experimental protozoal diseases and models Healing Infections Infectious diseases Interferon-gamma - genetics Interleukin-4 - genetics Leishmania - pathogenicity Leishmania - physiology Leishmaniasis Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Leishmaniasis, Cutaneous - physiopathology Lesions Macrophages Macrophages - drug effects Macrophages - parasitology Medical sciences Messenger RNA Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data Oligodeoxyribonucleotides Parasite hosts Parasites Parasitic diseases Polymerase Chain Reaction - methods Protozoal diseases Transforming Growth Factor beta - genetics Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta - physiology Transforming growth factors |
| title | Transforming Growth Factor-β in Leishmanial Infection: A Parasite Escape Mechanism |
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