The WD-40 repeat

An amino acid sequence motif, called the WD-40 repeat, has been found as a repeat in a large variety of proteins that do not share any obvious functional properties. At present, the function of the repeated motif is not known for any of these proteins. Interestingly, recent experiments in yeast indi...

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Bibliographic Details
Published in:FEBS Letters 1992-07, Vol.307 (2), p.131-134
Main Authors: van der Voorn, Loesje, Ploegh, Hidde L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
G protein β-subunit
Miscellaneous
Molecular Sequence Data
Peptides - chemistry
Protein family
Proteins
Repetitive Sequences, Nucleic Acid
TPR-gene family
WD-40 repeat
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Description
Summary:An amino acid sequence motif, called the WD-40 repeat, has been found as a repeat in a large variety of proteins that do not share any obvious functional properties. At present, the function of the repeated motif is not known for any of these proteins. Interestingly, recent experiments in yeast indicate that several proteins containing the WD-40 repeat are genetically associated with members of the TPR-family, a protein family that is characterized by the presence of another repeated motif of unknown function: the tetratricopeptide repeat. It is conceivable that proteins containing the WD-40 repeat interact physically with members of the TPR-family via their respective repeated motifs.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)80751-2