Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis

Inflammation plays an important role in the development of atherosclerosis. The gene for the counterinflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) is polymorphic, and high frequencies of allele 2 have been found to be associated with other inflammatory diseases. This study examined...

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Bibliographic Details
Published in:Stroke (1970) 2003-03, Vol.34 (3), p.790-793
Main Authors: WORRALL, Bradford B, AZHAR, Salman, NYQUIST, Paul A, ACKERMAN, Robert H, HAMM, Theresa L, DEGRABA, Thomas J
Format: Article
Language:English
Subjects:
Aged
Alleles
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Artery Diseases - genetics
Demography
Female
Gene Dosage
Gene Frequency
Genetic Carrier Screening
Genetic Predisposition to Disease
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein
Logistic Models
Male
Medical sciences
Odds Ratio
Polymorphism, Genetic
Risk Factors
ROC Curve
Sialoglycoproteins - genetics
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Summary:Inflammation plays an important role in the development of atherosclerosis. The gene for the counterinflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) is polymorphic, and high frequencies of allele 2 have been found to be associated with other inflammatory diseases. This study examined the association of allele and carrier frequencies of the IL-1ra gene with the presence of carotid atherosclerosis and plaque symptomaticity. A total of 328 subjects identified as having carotid atherosclerosis or no atherosclerosis (controls) participated. Blood was obtained for DNA determination. Frequency of allele 2 was significantly greater in patients with atherosclerosis compared with nonatherosclerotic subjects. No difference was seen between symptomatic and asymptomatic atherosclerosis patients. Noncarriage of allele 2 was associated with reduced likelihood of atherosclerosis (odds ratio [OR], 0.44; 95% CI, 0.27 to 0.71). The homozygous carrier state for allele 2 was associated with greater likelihood of atherosclerosis (unadjusted OR, 7.30; 95% CI, 2.31 to 22.94; adjusted OR, 13.78; 95% CI, 1.94 to 97.9). A gene-dose effect was detected. These data suggest that allele 2 of the IL-1ra gene represents a susceptibility factor in the development of carotid atherosclerosis. Further investigation appears warranted.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000057815.79289.EC