Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs

Twenty.four dogs with anal furunculosis were treated with cyclosporine once daily for 13 weeks at dosages of 1.5, 3.0, 5.0 or 7.5 mg/kg, and re.examined after six and 12 months. After 13 weeks the disease in six of the dogs was in remission, 11 were controlled or improved and seven had failed to res...

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Published in:Veterinary record 2003-02, Vol.152 (8), p.225-229
Main Authors: Doust, R., Griffiths, L. G., Sullivan, M.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Administration, Oral
adverse effects
Animals
Anus Diseases - drug therapy
Anus Diseases - pathology
cyclosporine
Cyclosporine - administration & dosage
Dog Diseases - drug therapy
Dog Diseases - pathology
Dogs
Dose-Response Relationship, Drug
Drug Administration Schedule
drug therapy
furunculosis
Furunculosis - drug therapy
Furunculosis - veterinary
remission
Treatment Outcome
vomiting
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cited_by cdi_FETCH-LOGICAL-b4176-f7a494862598e97480ce23049aeb48d7e30e1d001c8dce4471fdd57a3468a05e3
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creator Doust, R.
Griffiths, L. G.
Sullivan, M.
description Twenty.four dogs with anal furunculosis were treated with cyclosporine once daily for 13 weeks at dosages of 1.5, 3.0, 5.0 or 7.5 mg/kg, and re.examined after six and 12 months. After 13 weeks the disease in six of the dogs was in remission, 11 were controlled or improved and seven had failed to respond. The response of the dogs given the highest dose was significantly better than the response of the other groups taken together (P
doi_str_mv 10.1136/vr.152.8.225
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The 1 1 dogs that were improved or controlled after 13 weeks were either left untreated or were continued on cyclosporine medication for one to three months at a dosage of 1.5 to 7.5 mg/kg; the disease went into remission in four cases and remained controlled in the other seven, but four of the 1 1 cases relapsed during the 12 months following the treatment. The side effects observed included increased coat turnover and transient vomiting.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.152.8.225</identifier><identifier>PMID: 12625536</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>Adjuvants, Immunologic - administration &amp; dosage ; Administration, Oral ; adverse effects ; Animals ; Anus Diseases - drug therapy ; Anus Diseases - pathology ; cyclosporine ; Cyclosporine - administration &amp; dosage ; Dog Diseases - drug therapy ; Dog Diseases - pathology ; Dogs ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; drug therapy ; furunculosis ; Furunculosis - drug therapy ; Furunculosis - veterinary ; remission ; Treatment Outcome ; vomiting</subject><ispartof>Veterinary record, 2003-02, Vol.152 (8), p.225-229</ispartof><rights>British Veterinary Association. 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language eng
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subjects Adjuvants, Immunologic - administration & dosage
Administration, Oral
adverse effects
Animals
Anus Diseases - drug therapy
Anus Diseases - pathology
cyclosporine
Cyclosporine - administration & dosage
Dog Diseases - drug therapy
Dog Diseases - pathology
Dogs
Dose-Response Relationship, Drug
Drug Administration Schedule
drug therapy
furunculosis
Furunculosis - drug therapy
Furunculosis - veterinary
remission
Treatment Outcome
vomiting
title Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs
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