Palladium-Catalyzed Enantioselective Oxidation of Alcohols:  A Dramatic Rate Acceleration by Cs2CO3/t-BuOH

The addition of Cs2CO3 and t-BuOH provides a dramatic rate acceleration in the palladium-catalyzed aerobic oxidative kinetic resolution of secondary alcohols while maintaining the selectivity of the process.

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Bibliographic Details
Published in:Organic letters 2003-03, Vol.5 (6), p.835-837
Main Authors: Bagdanoff, Jeffrey T, Ferreira, Eric M, Stoltz, Brian M
Format: Article
Language:English
Subjects:
Alcohols - chemistry
Carbonates - chemistry
Catalysis
Cesium - chemistry
Kinetics
Oxidation-Reduction
Palladium - chemistry
Stereoisomerism
tert-Butyl Alcohol - chemistry
Online Access:Get full text
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Description
Summary:The addition of Cs2CO3 and t-BuOH provides a dramatic rate acceleration in the palladium-catalyzed aerobic oxidative kinetic resolution of secondary alcohols while maintaining the selectivity of the process.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol027463p