Anisotropic properties of tracheal smooth muscle tissue

The anisotropic (directional‐dependent) properties of contracting tracheal smooth muscle tissue are estimated from a computational model based on the experimental data of length‐dependent stiffness. The area changes are obtained at different muscle lengths from experiments in which stimulated muscle...

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Bibliographic Details
Published in:Journal of biomedical materials research 2003-04, Vol.65A (1), p.1-8
Main Authors: Sarma, P. A., Pidaparti, R. M., Meiss, R. A.
Format: Article
Language:English
Subjects:
Algorithms
Animals
Anisotropy
Biological and medical sciences
Biomechanical Phenomena
Compliance
Computer Simulation
Dogs
elastic properties
FEA
Finite Element Analysis
In Vitro Techniques
mechanics
Medical sciences
Muscle Contraction - physiology
Muscle, Smooth - physiology
Poisson Distribution
smooth muscle
Trachea - physiology
Transducers
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Summary:The anisotropic (directional‐dependent) properties of contracting tracheal smooth muscle tissue are estimated from a computational model based on the experimental data of length‐dependent stiffness. The area changes are obtained at different muscle lengths from experiments in which stimulated muscle undergoes unrestricted shortening. Then, through an interative process, the anisotropic properties are estimated by matching the area changes obtained from the finite element analysis to those derived from the experiments. The results obtained indicate that the anisotropy ratio (longitudinal stiffness to transverse stiffness) is about 4 when the smooth muscle undergoes 70% strain shortening, indicating that the transverse stiffness reduces as the longitudinal stiffness increases. It was found through a sensitivity analysis from the simulation model that the longitudinal stiffness and the in‐plane shear modulus are not very sensitive as compared to major Poisson's ratio to the area changes of the muscle tissue. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 1–8, 2003
ISSN:1549-3296
0021-9304
1552-4965
1097-4636
DOI:10.1002/jbm.a.10355