Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm

An abnormal distribution of the gap junction occurs in chronic atrial fibrillation (AF). There are conflicting data regarding changes in connexins (Cxs) in experimental models of AF. We examined whether patients with chronic AF have alterations in atrial Cxs. We analyzed the expression of Cx40 and C...

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Bibliographic Details
Published in:The American journal of cardiology 2003-03, Vol.91 (6), p.678-683
Main Authors: Nao, Tomoko, Ohkusa, Tomoko, Hisamatsu, Yuji, Inoue, Noriko, Matsumoto, Tomo, Yamada, Jutaro, Shimizu, Akihiko, Yoshiga, Yasuhiro, Yamagata, Toshihiko, Kobayashi, Shigeki, Yano, Masafumi, Hamano, Kimikazu, Matsuzaki, Masunori
Format: Article
Language:English
Subjects:
Adult
Aged
Atrial Fibrillation - genetics
Atrial Fibrillation - pathology
Atrial Fibrillation - physiopathology
Cardiovascular disease
Chronic Disease
Comparative analysis
Connexin 43 - analysis
Connexin 43 - genetics
Connexins - analysis
Connexins - genetics
Echocardiography
Electrocardiography
Female
Gap Junction alpha-5 Protein
Gene Expression - genetics
Heart Atria - diagnostic imaging
Heart Atria - pathology
Heart Atria - physiopathology
Heart Valve Diseases - genetics
Heart Valve Diseases - pathology
Heart Valve Diseases - physiopathology
Humans
Male
Middle Aged
Mitral Valve - diagnostic imaging
Mitral Valve - pathology
Mitral Valve - physiopathology
Myocardium - pathology
Patients
RNA, Messenger - analysis
RNA, Messenger - genetics
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Description
Summary:An abnormal distribution of the gap junction occurs in chronic atrial fibrillation (AF). There are conflicting data regarding changes in connexins (Cxs) in experimental models of AF. We examined whether patients with chronic AF have alterations in atrial Cxs. We analyzed the expression of Cx40 and Cx43 in the right atrial myocardium from 10 patients with mitral valvular disease (MVD) who had AF (MVD/AF), 10 patients with MVD who were in normal sinus rhythm (MVD/NSR), and 10 control patients in NSR (tissue obtained during coronary artery bypass surgery). Hemodynamic and echocardiographic data were obtained before surgery, and an electrophysiologic examination was performed during the operation. An immunohistochemical study was performed on atrial tissue. The relative expression level of Cx40 protein was significantly lower in MVD/AF patients (6.5 ± 4.6) than in either MVD/NSR patients (17.7 ± 8.9, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)03403-3