Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of bot...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5070), p.682-685
Main Authors: Arch, Robert, Wirth, Karin, Hofmann, Martin, Ponta, Helmut, Matzku, Siegfried, Herrlich, Peter, Zöller, Margot
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Monoclonal
Antigen presenting cells
B lymphocytes
B-Lymphocytes - immunology
Base Sequence
Blotting, Northern
Bone marrow cells
Cancer metastasis
Cell adhesion molecules
DNA - chemistry
Epitopes
Exons
Genetic aspects
Genetic Variation
Immune response
Lymph nodes
Lymphocyte Activation
Lymphocytes
Metastasis
Molecular Sequence Data
Multidisciplinary Sciences
Neoplasm Metastasis - immunology
Rats
Receptors, Lymphocyte Homing - analysis
Receptors, Lymphocyte Homing - genetics
Receptors, Lymphocyte Homing - immunology
Science & Technology
Science & Technology - Other Topics
T lymphocytes
T-Lymphocytes - immunology
Tumor Cells, Cultured
Tumors
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Description
Summary:A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1496383