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Substituted 4-methylquinolines as a new class of anti-tuberculosis agents
We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series 3d (MIC=6.25 μg/mL, Mycobacterium tuberculosis H37Rv strain) was synthesized in one step; thus is an attractive lead molecule for anti-tuberculosis drug de...
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Published in: | Bioorganic & medicinal chemistry letters 2003-03, Vol.13 (6), p.1051-1054 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series
3d (MIC=6.25 μg/mL,
Mycobacterium tuberculosis H37Rv strain) was synthesized in one step; thus is an attractive lead molecule for anti-tuberculosis drug development. The results of this study represent the discovery of ring-substituted 4-methylquinolines as new class of potential anti-tuberculosis agents.
The synthesis and antimycobacterial activities (
Mycobacterium tuberculosis H37Rv strain) for a series of ring-substituted 4-methylquinolines are described. The evaluation of cytotoxicity and efficacy against
M. avium and single-drug-resistant (SDR) strains of
M. tuberculosis for the most effective compound
3d (
R=
c-C
5H
9) are also reported. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(03)00074-X |