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Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
SHIGA toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans -Golgi network 1–9 . Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication 5–9 , but it is not known whether the enzymatica...
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| Published in: | Nature (London) 1992-08, Vol.358 (6386), p.510-512 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c488t-43b8dc0757e63fa5b2f26ea037af5515c7f9eb7a3c89bdd31f8a7f4700c4f8bf3 |
| container_end_page | 512 |
| container_issue | 6386 |
| container_start_page | 510 |
| container_title | Nature (London) |
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| creator | Sandvig, Kirsten Garred, Øystein Prydz, Kristian Kozlov, Juri V Hansen, Steen H van Deurs, Bo |
| description | SHIGA toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the
trans
-Golgi network
1–9
. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication
5–9
, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the fraiw-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle
10
, but retrograde transport of endocytosed material beyond the
trans
-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the
trans
-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol. |
| doi_str_mv | 10.1038/358510a0 |
| format | article |
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trans
-Golgi network
1–9
. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication
5–9
, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the fraiw-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle
10
, but retrograde transport of endocytosed material beyond the
trans
-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the
trans
-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/358510a0</identifier><identifier>PMID: 1641040</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacterial Proteins - drug effects ; Bacterial Proteins - metabolism ; Bacterial Proteins - ultrastructure ; Bacterial Toxins - metabolism ; Bacteriology ; Biological and medical sciences ; Biological Transport - drug effects ; Butyrates - pharmacology ; Butyric Acid ; Cellular biology ; Endocytosis ; endoplasmic reticulum ; Endoplasmic Reticulum - metabolism ; Fundamental and applied biological sciences. Psychology ; Golgi apparatus ; Golgi Apparatus - metabolism ; Humanities and Social Sciences ; Humans ; letter ; Medical research ; Microbiology ; multidisciplinary ; Nuclear Envelope - metabolism ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Science ; Science (multidisciplinary) ; Shiga toxin ; Shiga Toxins ; Toxins ; Translocation ; transport ; treatment ; Tumor Cells, Cultured</subject><ispartof>Nature (London), 1992-08, Vol.358 (6386), p.510-512</ispartof><rights>Springer Nature Limited 1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Aug 6, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-43b8dc0757e63fa5b2f26ea037af5515c7f9eb7a3c89bdd31f8a7f4700c4f8bf3</citedby><cites>FETCH-LOGICAL-c488t-43b8dc0757e63fa5b2f26ea037af5515c7f9eb7a3c89bdd31f8a7f4700c4f8bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5433708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1641040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandvig, Kirsten</creatorcontrib><creatorcontrib>Garred, Øystein</creatorcontrib><creatorcontrib>Prydz, Kristian</creatorcontrib><creatorcontrib>Kozlov, Juri V</creatorcontrib><creatorcontrib>Hansen, Steen H</creatorcontrib><creatorcontrib>van Deurs, Bo</creatorcontrib><title>Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>SHIGA toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the
trans
-Golgi network
1–9
. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication
5–9
, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the fraiw-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle
10
, but retrograde transport of endocytosed material beyond the
trans
-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the
trans
-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol.</description><subject>Bacterial Proteins - drug effects</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Proteins - ultrastructure</subject><subject>Bacterial Toxins - metabolism</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Biological Transport - drug effects</subject><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Cellular biology</subject><subject>Endocytosis</subject><subject>endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandvig, Kirsten</au><au>Garred, Øystein</au><au>Prydz, Kristian</au><au>Kozlov, Juri V</au><au>Hansen, Steen H</au><au>van Deurs, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1992-08-06</date><risdate>1992</risdate><volume>358</volume><issue>6386</issue><spage>510</spage><epage>512</epage><pages>510-512</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>SHIGA toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the
trans
-Golgi network
1–9
. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication
5–9
, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the fraiw-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle
10
, but retrograde transport of endocytosed material beyond the
trans
-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the
trans
-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1641040</pmid><doi>10.1038/358510a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1992-08, Vol.358 (6386), p.510-512 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73104170 |
| source | Nature |
| subjects | Bacterial Proteins - drug effects Bacterial Proteins - metabolism Bacterial Proteins - ultrastructure Bacterial Toxins - metabolism Bacteriology Biological and medical sciences Biological Transport - drug effects Butyrates - pharmacology Butyric Acid Cellular biology Endocytosis endoplasmic reticulum Endoplasmic Reticulum - metabolism Fundamental and applied biological sciences. Psychology Golgi apparatus Golgi Apparatus - metabolism Humanities and Social Sciences Humans letter Medical research Microbiology multidisciplinary Nuclear Envelope - metabolism Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Science Science (multidisciplinary) Shiga toxin Shiga Toxins Toxins Translocation transport treatment Tumor Cells, Cultured |
| title | Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum |
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