Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo)

Extracts from 11 plant species belonging to the Zingiberaceae were tested for antifungal activity using disc diffusion bioassays. Extracts from several members, especially Alpinia galanga, Curcuma zedoaria and Zingiber purpureum, were found to have pronounced inhibitory activities against a wide var...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-04, Vol.85 (2), p.289-293
Main Authors: Ficker, Christine E, Smith, Myron L, Susiarti, Siti, Leaman, Danna J, Irawati, Ç, Arnason, John T
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Antifungal resistance
Biological and medical sciences
Borneo
Borneo ethnobotany
Drug Resistance, Fungal
Ethnobotany
Fungi - drug effects
General pharmacology
Ginger
Humans
Medical sciences
Medicine, Traditional
Microbial Sensitivity Tests
Mycoses - microbiology
Pathogenic fungi
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Traditional phytomedicine
Zingiberaceae
Zingiberaceae - chemistry
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Summary:Extracts from 11 plant species belonging to the Zingiberaceae were tested for antifungal activity using disc diffusion bioassays. Extracts from several members, especially Alpinia galanga, Curcuma zedoaria and Zingiber purpureum, were found to have pronounced inhibitory activities against a wide variety of human pathogenic fungi, including strains resistant to the common antifungals amphotericin B and ketoconazole. As members of the Zingiberaceae are generally regarded as safe for human consumption, these species are excellent candidates for development as novel therapeutics.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00009-6