The impact of abdominal computerized tomography on the pretreatment staging and prognosis of small cell lung cancer

• Published in: Annals of oncology 1992-06, Vol.3 (6), p.469-474
• Main Authors: HIRSCH, F. R, OSTERLIND, K, INGEMANN JENSEN, L, THOMSEN, C, PETERS, K, JENSEN, F, HANSEN, H. H
• Format: Article
• Language: English
• Subjects: Abdominal Neoplasms - diagnostic imaging; Abdominal Neoplasms - mortality; Abdominal Neoplasms - secondary; Adult; Aged; Biological and medical sciences; Carcinoma, Small Cell - diagnostic imaging; Carcinoma, Small Cell - mortality; Carcinoma, Small Cell - secondary; Female; Humans; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Neoplasm Staging; Pneumology; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Rate; Tomography, X-Ray Computed; Tumors of the respiratory system and mediastinum; Ultrasonography
• ISSN: 0923-7534; 1569-8041
• DOI: 10.1093/oxfordjournals.annonc.a058237

One hundred six patients with small cell lung cancer (SCLC) were prospectively evaluated with regard to the prognostic impact of abdominal CT-scan in the pretreatment staging when compared to ultrasonography of the abdomen. Staging based on abdominal ultrasonography (US) plus bilateral bone marrow examinations gave as a result that 47 patients had extensive disease (ED) (44%). Seventeen patients with proven ED at time of referral were not included in this study. Abdominal CT-scan was performed in 76 of the 106 patients. Thirty patients of these 76 patients (39%) were classified as having ED after staging including US, but abdominal metastases were disclosed in another ten patients at the subsequent CT-scan. Liver metastases seen in two patients at ultrasonography were overlooked on the CT-scans. Median survival of the 36 patients classified as having limited disease (LD) after both procedures was 458 days, which was significantly better compared to 330 days for the ten patients with stage migration from LD to ED based on CT-scan, (p less than 0.05) and compared to 242 days in the 30 patients with ED demonstrated by both US and CT-scans (p less than 0.05). The prognostic impact of the CT-scan was further investigated in a multivariate analysis (Cox). Stage disease, performance status, LDH and alkaline phosphatase were significant prognostic factors in a proportional hazards model based on the original 106 patients. Patients in the best prognostic group were characterized by LD, good performance status (0-1) and normal LDH and alkaline phosphatase serum values. This group consisted of 22 patients (21%).