Analysis of the small GTPase gene superfamily of Arabidopsis

Small GTP-binding proteins regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cytoskeletal organization, and intracellular membrane trafficking. These proteins function as molecular switches that cycle between "active" and "inactive" s...

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Bibliographic Details
Published in:Plant physiology (Bethesda) 2003-03, Vol.131 (3), p.1191-1208
Main Authors: Vernoud, V, Horton, A.C, Yang, Z, Nielsen, E
Format: Article
Language:English
Subjects:
ADP-Ribosylation Factors - genetics
Arabidopsis - genetics
Arabidopsis Proteins - genetics
Arabidopsis thaliana
Arf GTPase
Arf GTPase-interacting protein
biochemical pathways
Biological and medical sciences
Cell biochemistry
Cell membranes
Cell physiology
classification
endocytosis
Fundamental and applied biological sciences. Psychology
Gene expression regulation
Genes. Genome
genome
Genome Analysis
Genomes
guanosinetriphosphatase
Molecular and cellular biology
Molecular genetics
Monomeric GTP-Binding Proteins - genetics
Multigene Family - genetics
Phylogeny
Physiological regulation
physiological transport
Plant cells
Plant growth regulators
Plant physiology and development
plant proteins
Plants
Proteins
rab GTP-Binding Proteins - genetics
Rab GTPase
Rab-interacting protein
ran GTP-Binding Protein - genetics
Ran GTPase
rho GTP-Binding Proteins - genetics
Rho GTPase
Rop-interacting protein
Signal Transduction - genetics
small-GTP-binding proteins
Terminology
Yeasts
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Summary:Small GTP-binding proteins regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cytoskeletal organization, and intracellular membrane trafficking. These proteins function as molecular switches that cycle between "active" and "inactive" states, and this cycle is linked to the binding and hydrolysis of GTP. The Arabidopsis genome contains 93 genes that encode small GTP-binding protein homologs. Phylogenetic analysis of these genes shows that plants contain Rab, Rho, Arf, and Ran GTPases, but no Ras GTPases. We have assembled complete lists of these small GTPases families, as well as accessory proteins that control their activity, and review what is known of the functions of individual members of these families in Arabidopsis. We also discuss the possible roles of these GTPases in relation to their similarity to orthologs with known functions and localizations in yeast and/or animal systems.
ISSN:0032-0889
1532-2548
DOI:10.1104/pp.013052