Evaluation of tissue kallikrein activity on survival time after acute coronary artery ligation in hypertensive rats

It is known that the tissue kallikrein–kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on surviv...

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Bibliographic Details
Published in:International immunopharmacology 2003-03, Vol.3 (3), p.329-334
Main Authors: Sharma, Jagdish N, Abbas, S.Atif, Yusof, A.Pauzi M, Shah, Rajesh P
Format: Article
Language:English
Subjects:
Animals
Aprotinin - pharmacology
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Cardiovascular system
Coronary artery ligation
Coronary Disease - drug therapy
Coronary Disease - physiopathology
Coronary Vessels - physiology
Heart Rate - drug effects
Hypertension - genetics
Hypertension - physiopathology
Hypertensive rats
Kallikreins - antagonists & inhibitors
Kallikreins - pharmacology
Ligation
Male
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Serine Proteinase Inhibitors - pharmacology
Survival
Survival time
Tissue kallikrein
Trasylol
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Summary:It is known that the tissue kallikrein–kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time with acute left coronary artery ligation for 15 min in spontaneously hypertensive rats (SHR). Tissue kallikrein (8 and 16 μg/kg, i.v.) treatment caused significant ( P
ISSN:1567-5769
1878-1705
DOI:10.1016/S1567-5769(02)00272-2