Loading…
Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions
In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was on the order of 8- and 800-fold more act...
Saved in:
Published in: | Journal of medicinal chemistry 1992-08, Vol.35 (16), p.2928-2938 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-a315t-7789fa4669b71ca917bab07da8afbf102b3259a3c3e662592518a541833a73f03 |
---|---|
cites | |
container_end_page | 2938 |
container_issue | 16 |
container_start_page | 2928 |
container_title | Journal of medicinal chemistry |
container_volume | 35 |
creator | Chandrakumar, Nizal S Stapelfeld, Awilda Beardsley, Patrick M Lopez, Oscar T Drury, Bridget Anthony, Elizabeth Savage, Michael A Williamson, L. Neil Reichman, Melvin |
description | In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was on the order of 8- and 800-fold more active than DPDPE in both delta and mu opioid radioligand binding assays, respectively, in rat neural membrane suspensions. Compound 4 was considerably more potent than DPDPE at inhibiting contractions of electrically-stimulated mouse vas deferens in vitro, and this effect was very sensitive to naltrindole, a delta-selective opioid antagonist. These observations can be taken as indication that 4 exerts its effects through delta opioid receptors. This interpretation is supported by the finding that the EC50 value of 4 derived in the smooth muscle assay is very similar to that derived in NG108-15 neuroblastoma cells, a preparation devoid of mu receptors. Unlike DPDPE, 4 exhibited significant, naloxone-sensitive, antinociceptive activity when administered systemically, as measured by inhibition of phenylbenzquinone-induced stretching in mice (ED50 = 2.1 mg/kg). Compound 4 also displayed significant antinociceptive activity following systemic administration as measured by its action in mice to increase latencies for tail withdrawal from radiant heat (ED50 = 50 mg/kg). Compound 4 did not produce morphine-like discriminative stimulus effects in rats trained to discriminate 3.0 mg/kg morphine from vehicle at doses ranging from 30 to 120 mg/kg. This observation can be interpreted as indication that within this dosage range there is an absence of morphine-like subjective effects. Physical dependence, however, could be induced in mice at higher doses of 4 under a progressively-graded, 4-day dose regimen. Congeners of 4 with amide bond surrogates for the Gly-Phe amide bond (oxymethylene, trans-double bond, and bismethylene isosteres) in the cyclic core of DPDPE were prepared in an attempt to increase the antinociceptive activity of 4. While some of the congeners were active in the in vitro assays, they did not display significant antinociceptive activity following systemic administration. The preparation of all the compounds was accomplished by solution-phase methods. The mechanisms which might underlie the biological and systemic activity of 4 are discussed. |
doi_str_mv | 10.1021/jm00094a002 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73111399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73111399</sourcerecordid><originalsourceid>FETCH-LOGICAL-a315t-7789fa4669b71ca917bab07da8afbf102b3259a3c3e662592518a541833a73f03</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEKkvhxBnJB8QeqBd_JPGGW1VgQdqKShQJUVWW40xYb5042A4i_46fhqusCkKcbL_z-B3PjLPsKSUrShh9te8IIVWuCGH3sgUtGMH5muT3s0VSGGYl4w-zRyHsE8Yp40fZEeWMl0Issl-nvbLuW0CuRXEHaNWAjWqF3GCcaZAHDUN0HgWwoKP5AUhP2hqNhqSbBtDVfL6-YvgNHqA32lirOtPDSfGvco2hv4Fhp6zpXyO2PCmXuDEdxN1k4-RdSAxSfYM2duL4Ygc5SvdSktol0QQXInhAYaxDNHGMxvXhcfagVTbAk8N6nH1-9_by7D3eftx8ODvdYsVpEbEQ66pVeVlWtaBaVVTUqiaiUWvV1m1qY81ZUSmuOZRl2rGCrlWR0zXnSvCW8OPsxew7ePd9hBBlZ4KGVFkPbgxScEopr6oEvpxBnQoKHlo5eNMpP0lK5O285F_zSvSzg-1Yd9D8YecBpfjzQ1wFrWzrVa9NuMOKvBSVyBOGZ8ykFv28Cyt_I0vBRSEvLz7Jc1J82X7dnMtb2-XMKx3k3o0-_YLw3wf-BkLEupA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73111399</pqid></control><display><type>article</type><title>Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions</title><source>ACS CRKN Legacy Archives</source><creator>Chandrakumar, Nizal S ; Stapelfeld, Awilda ; Beardsley, Patrick M ; Lopez, Oscar T ; Drury, Bridget ; Anthony, Elizabeth ; Savage, Michael A ; Williamson, L. Neil ; Reichman, Melvin</creator><creatorcontrib>Chandrakumar, Nizal S ; Stapelfeld, Awilda ; Beardsley, Patrick M ; Lopez, Oscar T ; Drury, Bridget ; Anthony, Elizabeth ; Savage, Michael A ; Williamson, L. Neil ; Reichman, Melvin</creatorcontrib><description>In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was on the order of 8- and 800-fold more active than DPDPE in both delta and mu opioid radioligand binding assays, respectively, in rat neural membrane suspensions. Compound 4 was considerably more potent than DPDPE at inhibiting contractions of electrically-stimulated mouse vas deferens in vitro, and this effect was very sensitive to naltrindole, a delta-selective opioid antagonist. These observations can be taken as indication that 4 exerts its effects through delta opioid receptors. This interpretation is supported by the finding that the EC50 value of 4 derived in the smooth muscle assay is very similar to that derived in NG108-15 neuroblastoma cells, a preparation devoid of mu receptors. Unlike DPDPE, 4 exhibited significant, naloxone-sensitive, antinociceptive activity when administered systemically, as measured by inhibition of phenylbenzquinone-induced stretching in mice (ED50 = 2.1 mg/kg). Compound 4 also displayed significant antinociceptive activity following systemic administration as measured by its action in mice to increase latencies for tail withdrawal from radiant heat (ED50 = 50 mg/kg). Compound 4 did not produce morphine-like discriminative stimulus effects in rats trained to discriminate 3.0 mg/kg morphine from vehicle at doses ranging from 30 to 120 mg/kg. This observation can be interpreted as indication that within this dosage range there is an absence of morphine-like subjective effects. Physical dependence, however, could be induced in mice at higher doses of 4 under a progressively-graded, 4-day dose regimen. Congeners of 4 with amide bond surrogates for the Gly-Phe amide bond (oxymethylene, trans-double bond, and bismethylene isosteres) in the cyclic core of DPDPE were prepared in an attempt to increase the antinociceptive activity of 4. While some of the congeners were active in the in vitro assays, they did not display significant antinociceptive activity following systemic administration. The preparation of all the compounds was accomplished by solution-phase methods. The mechanisms which might underlie the biological and systemic activity of 4 are discussed.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00094a002</identifier><identifier>PMID: 1323677</identifier><identifier>CODEN: JMCMAR</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Amides - chemistry ; Amino Acid Sequence ; Analgesics - metabolism ; Analgesics - pharmacology ; Animals ; Chemistry ; Enkephalin, D-Penicillamine (2,5) ; Enkephalins - chemistry ; Enkephalins - metabolism ; Enkephalins - pharmacology ; Exact sciences and technology ; Glycine - chemistry ; Male ; Mice ; Molecular Sequence Data ; Muscle Contraction - drug effects ; Neuroblastoma ; Organic chemistry ; Peptides ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - metabolism ; Peptides, Cyclic - pharmacology ; Phenylalanine - chemistry ; Preparations and properties ; Radioligand Assay ; Rats ; Rats, Inbred Strains ; Receptors, Opioid - metabolism ; Receptors, Opioid, delta ; Structure-Activity Relationship ; Substrate Specificity ; Tumor Cells, Cultured ; Tyrosine - analogs & derivatives ; Tyrosine - chemistry ; Vas Deferens - physiology</subject><ispartof>Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.2928-2938</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a315t-7789fa4669b71ca917bab07da8afbf102b3259a3c3e662592518a541833a73f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00094a002$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00094a002$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,27063,27923,27924,56765,56815</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5467974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1323677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandrakumar, Nizal S</creatorcontrib><creatorcontrib>Stapelfeld, Awilda</creatorcontrib><creatorcontrib>Beardsley, Patrick M</creatorcontrib><creatorcontrib>Lopez, Oscar T</creatorcontrib><creatorcontrib>Drury, Bridget</creatorcontrib><creatorcontrib>Anthony, Elizabeth</creatorcontrib><creatorcontrib>Savage, Michael A</creatorcontrib><creatorcontrib>Williamson, L. Neil</creatorcontrib><creatorcontrib>Reichman, Melvin</creatorcontrib><title>Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was on the order of 8- and 800-fold more active than DPDPE in both delta and mu opioid radioligand binding assays, respectively, in rat neural membrane suspensions. Compound 4 was considerably more potent than DPDPE at inhibiting contractions of electrically-stimulated mouse vas deferens in vitro, and this effect was very sensitive to naltrindole, a delta-selective opioid antagonist. These observations can be taken as indication that 4 exerts its effects through delta opioid receptors. This interpretation is supported by the finding that the EC50 value of 4 derived in the smooth muscle assay is very similar to that derived in NG108-15 neuroblastoma cells, a preparation devoid of mu receptors. Unlike DPDPE, 4 exhibited significant, naloxone-sensitive, antinociceptive activity when administered systemically, as measured by inhibition of phenylbenzquinone-induced stretching in mice (ED50 = 2.1 mg/kg). Compound 4 also displayed significant antinociceptive activity following systemic administration as measured by its action in mice to increase latencies for tail withdrawal from radiant heat (ED50 = 50 mg/kg). Compound 4 did not produce morphine-like discriminative stimulus effects in rats trained to discriminate 3.0 mg/kg morphine from vehicle at doses ranging from 30 to 120 mg/kg. This observation can be interpreted as indication that within this dosage range there is an absence of morphine-like subjective effects. Physical dependence, however, could be induced in mice at higher doses of 4 under a progressively-graded, 4-day dose regimen. Congeners of 4 with amide bond surrogates for the Gly-Phe amide bond (oxymethylene, trans-double bond, and bismethylene isosteres) in the cyclic core of DPDPE were prepared in an attempt to increase the antinociceptive activity of 4. While some of the congeners were active in the in vitro assays, they did not display significant antinociceptive activity following systemic administration. The preparation of all the compounds was accomplished by solution-phase methods. The mechanisms which might underlie the biological and systemic activity of 4 are discussed.</description><subject>Amides - chemistry</subject><subject>Amino Acid Sequence</subject><subject>Analgesics - metabolism</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Chemistry</subject><subject>Enkephalin, D-Penicillamine (2,5)</subject><subject>Enkephalins - chemistry</subject><subject>Enkephalins - metabolism</subject><subject>Enkephalins - pharmacology</subject><subject>Exact sciences and technology</subject><subject>Glycine - chemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Muscle Contraction - drug effects</subject><subject>Neuroblastoma</subject><subject>Organic chemistry</subject><subject>Peptides</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - metabolism</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Phenylalanine - chemistry</subject><subject>Preparations and properties</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - metabolism</subject><subject>Receptors, Opioid, delta</subject><subject>Structure-Activity Relationship</subject><subject>Substrate Specificity</subject><subject>Tumor Cells, Cultured</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - chemistry</subject><subject>Vas Deferens - physiology</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNptkk1v1DAQhiMEKkvhxBnJB8QeqBd_JPGGW1VgQdqKShQJUVWW40xYb5042A4i_46fhqusCkKcbL_z-B3PjLPsKSUrShh9te8IIVWuCGH3sgUtGMH5muT3s0VSGGYl4w-zRyHsE8Yp40fZEeWMl0Issl-nvbLuW0CuRXEHaNWAjWqF3GCcaZAHDUN0HgWwoKP5AUhP2hqNhqSbBtDVfL6-YvgNHqA32lirOtPDSfGvco2hv4Fhp6zpXyO2PCmXuDEdxN1k4-RdSAxSfYM2duL4Ygc5SvdSktol0QQXInhAYaxDNHGMxvXhcfagVTbAk8N6nH1-9_by7D3eftx8ODvdYsVpEbEQ66pVeVlWtaBaVVTUqiaiUWvV1m1qY81ZUSmuOZRl2rGCrlWR0zXnSvCW8OPsxew7ePd9hBBlZ4KGVFkPbgxScEopr6oEvpxBnQoKHlo5eNMpP0lK5O285F_zSvSzg-1Yd9D8YecBpfjzQ1wFrWzrVa9NuMOKvBSVyBOGZ8ykFv28Cyt_I0vBRSEvLz7Jc1J82X7dnMtb2-XMKx3k3o0-_YLw3wf-BkLEupA</recordid><startdate>19920807</startdate><enddate>19920807</enddate><creator>Chandrakumar, Nizal S</creator><creator>Stapelfeld, Awilda</creator><creator>Beardsley, Patrick M</creator><creator>Lopez, Oscar T</creator><creator>Drury, Bridget</creator><creator>Anthony, Elizabeth</creator><creator>Savage, Michael A</creator><creator>Williamson, L. Neil</creator><creator>Reichman, Melvin</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920807</creationdate><title>Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions</title><author>Chandrakumar, Nizal S ; Stapelfeld, Awilda ; Beardsley, Patrick M ; Lopez, Oscar T ; Drury, Bridget ; Anthony, Elizabeth ; Savage, Michael A ; Williamson, L. Neil ; Reichman, Melvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a315t-7789fa4669b71ca917bab07da8afbf102b3259a3c3e662592518a541833a73f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amides - chemistry</topic><topic>Amino Acid Sequence</topic><topic>Analgesics - metabolism</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Chemistry</topic><topic>Enkephalin, D-Penicillamine (2,5)</topic><topic>Enkephalins - chemistry</topic><topic>Enkephalins - metabolism</topic><topic>Enkephalins - pharmacology</topic><topic>Exact sciences and technology</topic><topic>Glycine - chemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Muscle Contraction - drug effects</topic><topic>Neuroblastoma</topic><topic>Organic chemistry</topic><topic>Peptides</topic><topic>Peptides, Cyclic - chemistry</topic><topic>Peptides, Cyclic - metabolism</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Phenylalanine - chemistry</topic><topic>Preparations and properties</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - metabolism</topic><topic>Receptors, Opioid, delta</topic><topic>Structure-Activity Relationship</topic><topic>Substrate Specificity</topic><topic>Tumor Cells, Cultured</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - chemistry</topic><topic>Vas Deferens - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandrakumar, Nizal S</creatorcontrib><creatorcontrib>Stapelfeld, Awilda</creatorcontrib><creatorcontrib>Beardsley, Patrick M</creatorcontrib><creatorcontrib>Lopez, Oscar T</creatorcontrib><creatorcontrib>Drury, Bridget</creatorcontrib><creatorcontrib>Anthony, Elizabeth</creatorcontrib><creatorcontrib>Savage, Michael A</creatorcontrib><creatorcontrib>Williamson, L. Neil</creatorcontrib><creatorcontrib>Reichman, Melvin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandrakumar, Nizal S</au><au>Stapelfeld, Awilda</au><au>Beardsley, Patrick M</au><au>Lopez, Oscar T</au><au>Drury, Bridget</au><au>Anthony, Elizabeth</au><au>Savage, Michael A</au><au>Williamson, L. Neil</au><au>Reichman, Melvin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1992-08-07</date><risdate>1992</risdate><volume>35</volume><issue>16</issue><spage>2928</spage><epage>2938</epage><pages>2928-2938</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><abstract>In order to develop systemically-active opioid peptides, the delta-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Compound 4 was on the order of 8- and 800-fold more active than DPDPE in both delta and mu opioid radioligand binding assays, respectively, in rat neural membrane suspensions. Compound 4 was considerably more potent than DPDPE at inhibiting contractions of electrically-stimulated mouse vas deferens in vitro, and this effect was very sensitive to naltrindole, a delta-selective opioid antagonist. These observations can be taken as indication that 4 exerts its effects through delta opioid receptors. This interpretation is supported by the finding that the EC50 value of 4 derived in the smooth muscle assay is very similar to that derived in NG108-15 neuroblastoma cells, a preparation devoid of mu receptors. Unlike DPDPE, 4 exhibited significant, naloxone-sensitive, antinociceptive activity when administered systemically, as measured by inhibition of phenylbenzquinone-induced stretching in mice (ED50 = 2.1 mg/kg). Compound 4 also displayed significant antinociceptive activity following systemic administration as measured by its action in mice to increase latencies for tail withdrawal from radiant heat (ED50 = 50 mg/kg). Compound 4 did not produce morphine-like discriminative stimulus effects in rats trained to discriminate 3.0 mg/kg morphine from vehicle at doses ranging from 30 to 120 mg/kg. This observation can be interpreted as indication that within this dosage range there is an absence of morphine-like subjective effects. Physical dependence, however, could be induced in mice at higher doses of 4 under a progressively-graded, 4-day dose regimen. Congeners of 4 with amide bond surrogates for the Gly-Phe amide bond (oxymethylene, trans-double bond, and bismethylene isosteres) in the cyclic core of DPDPE were prepared in an attempt to increase the antinociceptive activity of 4. While some of the congeners were active in the in vitro assays, they did not display significant antinociceptive activity following systemic administration. The preparation of all the compounds was accomplished by solution-phase methods. The mechanisms which might underlie the biological and systemic activity of 4 are discussed.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>1323677</pmid><doi>10.1021/jm00094a002</doi><tpages>11</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0022-2623 |
ispartof | Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.2928-2938 |
issn | 0022-2623 1520-4804 |
language | eng |
recordid | cdi_proquest_miscellaneous_73111399 |
source | ACS CRKN Legacy Archives |
subjects | Amides - chemistry Amino Acid Sequence Analgesics - metabolism Analgesics - pharmacology Animals Chemistry Enkephalin, D-Penicillamine (2,5) Enkephalins - chemistry Enkephalins - metabolism Enkephalins - pharmacology Exact sciences and technology Glycine - chemistry Male Mice Molecular Sequence Data Muscle Contraction - drug effects Neuroblastoma Organic chemistry Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Phenylalanine - chemistry Preparations and properties Radioligand Assay Rats Rats, Inbred Strains Receptors, Opioid - metabolism Receptors, Opioid, delta Structure-Activity Relationship Substrate Specificity Tumor Cells, Cultured Tyrosine - analogs & derivatives Tyrosine - chemistry Vas Deferens - physiology |
title | Analogs of the .delta. opioid receptor selective cyclic peptide [cyclic][2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T15%3A18%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analogs%20of%20the%20.delta.%20opioid%20receptor%20selective%20cyclic%20peptide%20%5Bcyclic%5D%5B2-D-penicillamine,5-D-penicillamine%5D-enkephalin:%202',6'-dimethyltyrosine%20and%20Gly3-Phe4%20amide%20bond%20isostere%20substitutions&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Chandrakumar,%20Nizal%20S&rft.date=1992-08-07&rft.volume=35&rft.issue=16&rft.spage=2928&rft.epage=2938&rft.pages=2928-2938&rft.issn=0022-2623&rft.eissn=1520-4804&rft.coden=JMCMAR&rft_id=info:doi/10.1021/jm00094a002&rft_dat=%3Cproquest_cross%3E73111399%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a315t-7789fa4669b71ca917bab07da8afbf102b3259a3c3e662592518a541833a73f03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73111399&rft_id=info:pmid/1323677&rfr_iscdi=true |