FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study

To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA). This allelic association study examined the FcgammaRIIIA-158V/F polymorphism for association with RA. A novel sing...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2003-04, Vol.42 (4), p.528-533
Main Authors: Morgan, A W, Keyte, V H, Babbage, S J, Robinson, J I, Ponchel, F, Barrett, J H, Bhakta, B B, Bingham, S J, Buch, M H, Conaghan, P G, Gough, A, Green, M, Lawson, C A, Pease, C T, Markham, A F, Ollier, W E R, Emery, P, Worthington, J, Isaacs, J D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Arthritis, Rheumatoid - genetics
Cohort Studies
Female
Genetic Predisposition to Disease
Genotype
HLA-DR Antigens - analysis
HLA-DRB1 Chains
Humans
Male
Middle Aged
Polymerase Chain Reaction - methods
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Receptors, IgG - genetics
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Summary:To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA). This allelic association study examined the FcgammaRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. The FcgammaRIIIA-158V allele was associated with both RA (P=0.02) and nodules (P=0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. We have developed a novel assay to genotype the FcgammaRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se.
ISSN:1462-0324