Lipomas of the oral cavity: clinical findings, histological classification and proliferative activity of 46 cases

Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. Although relatively common, few large series of intraoral lipomas and its variants are seen in the literature. Therefore, the authors present the clinical, histological and immunohistochemical features of 46 cases of intraoral lipo...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2003-02, Vol.32 (1), p.49-53
Main Authors: Fregnani, E.R., Pires, F.R., Falzoni, R., Lopes, M.A., Vargas, P.A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Brazil
Cell Division
Child
Dentistry
Female
Humans
Immunohistochemistry
intramuscular lipoma
ki-67 antigen
Ki-67 Antigen - analysis
Lip Neoplasms - pathology
lipoma
Lipoma - classification
Lipoma - pathology
Male
Middle Aged
Mouth Floor - pathology
Mouth Mucosa - pathology
Mouth Neoplasms - pathology
oral mucosa
proliferating cell nuclear antigen
Proliferating Cell Nuclear Antigen - analysis
Retrospective Studies
Salivary Gland Neoplasms - pathology
Salivary Glands, Minor - pathology
sialolipoma
spindle cell lipoma
Tongue Neoplasms - pathology
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Summary:Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. Although relatively common, few large series of intraoral lipomas and its variants are seen in the literature. Therefore, the authors present the clinical, histological and immunohistochemical features of 46 cases of intraoral lipomas reviewed from the files of the University of Campinas Dental School from 1970 to 2001. Most of the cases affected adults, without gender predilection, and the main involved sites were the buccal mucosa (21 cases), tongue (six cases), lips (six cases) and floor of mouth (five cases). The histological analysis revealed 21 cases of lipoma, 18 fibrolipomas, four intramuscular lipomas, two minor salivary gland lipomas and one spindle cell lipoma. PCNA and ki-67 expression indexes were higher in spindle cell lipoma, intramuscular lipomas and fibrolipomas compared to common lipomas, but the differences were not statistically significant. All lesions were removed surgically and none showed recurrence, regardless of the various proliferative activities.
ISSN:0901-5027
1399-0020
DOI:10.1054/ijom.2002.0317